Condition

Headache clinical trials and research

• 27Clinical trials
• 28NIH research projects
• 7Countries

Newest Headache clinical trials

All recruiting trials (27)

• HEADS Registry: Headache, Ear, Auditory, Dizziness, and Sinus</n> Registry

  This registry tests whether collecting online symptom reports from adults in the U.S. with sinus, vestibular, ear, or headache symptoms can help improve diagnosis and treatment.

  Recruiting Association of Migraine Disorders · North Kingstown, Rhode Island · NCT07754266

• Immediate neck manual therapy effects on atlas position and neck muscles

  This trial tests two upper neck manual therapy techniques to see their immediate effect on neck alignment, atlas position, and a neck muscle shape in adults with head and neck pain or headaches.

  Recruiting Florida Gulf Coast University · Fort Myers, Florida · NCT07725198

• Vitamin IV lidocaine before fundal pressure to prevent headache after cesarean using spinal anesthesia

  This trial tests whether a single intravenous dose of lidocaine given before fundal pressure during cesarean delivery reduces the chance or severity of headache.

  Recruiting Phase 3 Tanta University · Tanta, Gharbia Governorate · NCT07661758

• Muscle Position and Dry Needling Efficacy

  This study tests whether the position of the upper trapezius during dry needling changes pain and function for people with chronic neck pain.

  Recruiting at 2 sites University of Alcala · Alcalá de Henares, Madrid and 1 other locations · NCT07629141

• Gentle ear vagus nerve stimulation to reduce headache after aneurysm stent coiling

  This study will try a noninvasive ear vagus nerve stimulation device to see if it reduces postoperative headaches in adults having stent-assisted coiling or flow-diverter treatment for unruptured brain aneurysms.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07479082

• Surgical masks versus N95 masks for operating room nurses' symptoms from surgical smoke

  This test compares whether surgical masks or N95 masks reduce physical symptoms from surgical smoke in operating room nurses.

  Recruiting Bartın Unıversity · Bartın, Bartın · NCT07404956

• Localized lidocaine injection into the middle meningeal artery for chronic migraine relief

  This phase 2 trial tests whether injecting lidocaine into brain arteries can reduce chronic migraine headaches in adults.

  Recruiting Phase 2 Cooper Norcross Health · Camden, New Jersey · NCT07361549

• Using machine learning to guide rTMS for Gulf War Illness–related headaches and body pain

  This trial will try using a machine learning model on resting brain scans to predict which active rTMS treatment will best reduce headaches and body pain in veterans with Gulf War Illness.

  Recruiting Veterans Medical Research Foundation · San Diego, California · NCT07325513

• Lidocaine with or without steroid infusion into the middle meningeal artery for headaches after aneurysmal subarachnoid hemorrhage

  This study will try an infusion of lidocaine, with or without a steroid, into the middle meningeal artery to see if it reduces severe headaches and opioid use in adults recovering from aneurysmal subarachnoid hemorrhage.

  Recruiting Phase 2 The University of Texas Medical Branch, Galveston · Galveston, Texas · NCT07294118

• Headache registration and follow-up program at Tongji Hospital

  This program will collect clinical records, imaging, questionnaires, and blood samples from people aged 6–70 with diagnosed headaches to build a large database to help develop better diagnosis and treatments.

  Recruiting Tongji Hospital · Wuhan, Hubei · NCT07269561

• Intranasal sphenopalatine ganglion block for headache after a ruptured brain aneurysm

  This will test whether spraying a numbing medicine into the back of the nose can reduce severe headache in adults recovering from a ruptured brain aneurysm.

  Recruiting Phase 4 Wright State University · Dayton, Ohio · NCT07116408

• Concussion recovery and support program for young adults

  This pilot randomized trial will test whether a six-session online therapy called CRISP helps 18–30-year-olds with concussion-related headaches feel and function better.

  Recruiting at 2 sites Seattle Children's Hospital · Seattle, Washington and 1 other locations · NCT07097792

• Using external trigeminal nerve stimulation to treat migraines in pregnant women

  This study is trying to see if a device that stimulates a nerve in the face can safely help pregnant women with migraines feel better.

  Recruiting Cefaly Technology · Darien, Connecticut · NCT06788977

• Aerobic exercise to improve sensory, muscle, and psychosocial symptoms in women with migraine

  This trial will test whether supervised aerobic exercise plus one pain neuroscience education session helps women aged 18–48 with migraine reduce disability and improve sensory, musculoskeletal, and psychosocial symptoms.

  Recruiting University of Sao Paulo · Ribeirão Preto, São Paulo · NCT06716489

• Effects of testosterone on headaches and brain development in transmasculine youth

  This study is testing how testosterone therapy affects headaches and brain development in transmasculine youth aged 12-20 who were assigned female at birth.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT06670053

• Transnasal nerve block for headaches after brain hemorrhage

  This study is testing if a special nose treatment can help reduce headaches in people who have had a brain hemorrhage and see if it can lower their need for pain medication.

  Recruiting Phase 2/3 University of California, Davis · Sacramento, California · NCT06621329

• IV lidocaine for headaches after non‑traumatic subarachnoid hemorrhage

  This project will try an IV lidocaine infusion to see if it reduces moderate to severe headaches in adults who had a non‑traumatic subarachnoid hemorrhage.

  Recruiting University of Kansas Medical Center · Wichita, Kansas · NCT06582810

• Using open-label placebo to improve sleep and pain in chronic pain patients

  This study is testing if a special type of placebo treatment can help people with chronic jaw pain sleep better and feel less pain.

  Recruiting University of Maryland, Baltimore · Baltimore, Maryland · NCT06225817

• Comparing headache characteristics in patients with different flexion-rotation test results

  This study is trying to see how headaches are different in people with cervicogenic headaches based on whether their flexion-rotation test results are positive or negative.

  Recruiting University Ghent · Ghent, Oost-Vlaanderen · NCT06134791

• Using magnetic stimulation to treat headaches after concussions

  This study is testing if a special type of brain stimulation can help people with chronic headaches after a concussion feel better without the side effects of regular medications.

  Recruiting Phase 1 State University of New York - Upstate Medical University · Syracuse, New York · NCT06112093

• Personalized brain stimulation for long-term symptoms after concussion

  This study will try personalized, noninvasive brain stimulation (TMS) to reduce dizziness, headaches, memory problems, and other lasting symptoms in adults aged 18–65 after a concussion.

  Recruiting Phase 2 University of California, Los Angeles · Westwood, Los Angeles, California · NCT06073886

• Pterygopalatine fossa nerve block for headaches after subarachnoid hemorrhage

  This study is testing if a special nerve block can help people who have had a brain bleed feel better by reducing their headaches.

  Recruiting at 12 sites Phase 2 University of Florida · Gainesville, Florida and 12 other locations · NCT06008795

• Comparing telehealth cognitive behavioral therapy for youth with migraines

  This study is testing whether online therapy for kids and teens with migraines works better when combined with medication or on its own.

  Recruiting at 15 sites Children's Hospital Medical Center, Cincinnati · Birmingham, Alabama and 14 other locations · NCT05889624

• Using needle electrolysis on the ear to treat headaches

  This study is testing if a new treatment using tiny needles on the ear can help reduce headaches and improve symptoms for people who suffer from them.

  Recruiting University of Alcala · Alcalá de Henares, Madrid · NCT05662722

• Evaluating a lifestyle intervention for chronic migraine management

  This study is testing a new lifestyle program to see if it can help people with chronic migraines feel better compared to a control group.

  Recruiting Mayo Clinic · Phoenix, Arizona · NCT05415020

• Combining brain stimulation and therapy for headaches after mild brain injuries

  This study is testing if combining brain stimulation with therapy can help veterans and active military personnel manage headaches caused by mild brain injuries.

  Recruiting Veterans Medical Research Foundation · San Diego, California · NCT05176392

• Evaluating Medrol Dose Pack for treating headaches after concussions

  This study is testing if a medication called Medrol can help people with headaches after a concussion feel better and get back to their normal activities faster.

  Recruiting Northwell Health · Manhasset, New York · NCT04685772

NIH-funded research (28)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Deep learning approach to diagnosing chronic headaches and facial pain

  A new AI-based method aims to improve how doctors diagnose chronic headache and facial pain by using a large, long-term set of patient data.

  NIH research Rochester Institute of Technology · Rochester, United States · NIH-11579147

• Understanding why some head injuries lead to long-lasting headaches and pain sensations

  This grant tests how early inflammation after repeating mild brain injuries might set up long-lasting headaches and widespread pain, using a rat model to study brain circuits involved in pain.

  NIH research University of Pr Cayey University Coll · Cayey, United States · NIH-11425060

• Bispecific antibody therapy targeting CGRP and CCL2 for chronic post-traumatic headache

  A new non-opioid treatment using a dual-targeting antibody aims to prevent and treat chronic post-traumatic headache in people who have suffered a mild traumatic brain injury.

  NIH research Washington University · Saint Louis, United States · NIH-11418123

• Non-Addictive Nose Spray Nerve Block for Quick Migraine Relief

  A new nasal nerve-blocking treatment being tested to relieve migraine attacks quickly without addictive drugs.

  NIH research Olfax, LLC · Asheville, United States · NIH-11405684

• Pediatric Headache in the COVID era: learning from kids’ pain with smart data and brain signals

  A pediatric-focused project uses computer learning and brain-behavior data to better classify headache types in kids and guide personalized treatment.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11396961

• Meningeal nerve signals and immune cells in migraine pain

  This NIH grant explores how nerve signals in the brain’s meninges interact with immune cells to trigger migraine pain, with results aimed at improving treatments for people who experience migraines.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11390265

• Sleep disruption after mild brain injury may drive chronic post-traumatic headaches

  A study of people who have had a mild traumatic brain injury to see if sleep problems help explain why headaches linger, and whether a drug called prazosin could help.

  NIH research Seattle Inst for Biomedical/clinical Res · Seattle, United States · NIH-11353962

• NerveAI: smarter diagnosis and treatment planning for headache pain

  A new AI-assisted tool plus high-resolution MRI will help doctors diagnose occipital neuralgia more accurately and plan personalized treatments for people with headaches.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11347158

• How puberty hormones and testosterone affect headaches in transmasculine teens

  This project looks at whether starting gender‑affirming testosterone changes how often or how bad headaches are in transmasculine adolescents.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11322981

• Brain and head-nerve pathways behind migraine pain

  Researchers are comparing how specific brain regions and head nerves produce migraine headache in people who get migraines, including those with aura.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11309603

• How the trigeminal ganglion's internal clock affects headache pain

  This project looks at whether the internal clock in the trigeminal ganglion helps explain daily patterns of pain in migraine and cluster headache.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11300226

• Boosting the body's endocannabinoid system to relieve headaches

  Researchers are trying to increase natural endocannabinoid levels to reduce migraine and medication-overuse headaches in men and women.

  NIH research University of Arizona · Tucson, United States · NIH-11258034

• Investigating headaches after concussions in young people

  This study is looking at how concussions can cause long-lasting headaches in kids and teens, and it hopes to find clues in the brain that can help doctors better treat these headaches and improve care for young patients.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11127677

• Understanding Sleep Problems and Headaches After Mild Brain Injury

  This research explores how sleep problems after a mild brain injury might lead to long-lasting headaches, hoping to find new ways to help patients.

  NIH research Seattle Inst for Biomedical/clinical Res · Seattle, United States · NIH-11126814

• Personalizing care for children's long-term headaches after COVID-19

  This project uses brain and behavior tests plus machine learning to sort different types of chronic headaches in children and teens so treatments can be better matched.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11093400

• How the body's internal clock affects headache pain responses

  This study is looking at how our body's internal clock affects pain, especially for people who suffer from headaches like migraines and cluster headaches, to find better ways to help manage their pain.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11075791

• Understanding how different brain areas contribute to headaches.

  This study is looking at how certain parts of the brain, especially the thalamus, help cause migraines, and by understanding this better, we hope to find new ways to help people who suffer from these headaches.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11066540

• How puberty hormones affect headaches in transmasculine teens

  This study is looking at how taking testosterone affects headaches in transmasculine teens, hoping to find ways to help manage their headaches better.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11023071

• Exploring the role of the endocannabinoid system in treating headaches

  This study is looking at how problems with a system in our body called the endocannabinoid system might cause headaches, and it aims to find new ways to help people with headaches by testing different treatments in rats to see how they work and if men and women respond differently.

  NIH research University of Arizona · Tucson, United States · NIH-11004080

• How brain surface cells may trigger migraine pain

  Sees if overactive brain surface cells release chemicals that wake up pain nerves and cause migraine in adults.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11001164

• Identifying who will develop long-lasting headaches after a concussion

  This study is looking to find a way to predict which people might have long-lasting headaches after a concussion, so that doctors can start the right treatment sooner and help them feel better faster.

  NIH research Mayo Clinic Arizona · Scottsdale, United States · NIH-10897709

• Assessing headaches in children to identify serious brain issues

  This study is looking at kids who go to the emergency room with headaches to find out which ones might need extra tests for serious brain issues, helping doctors decide when it's really necessary to do scans while keeping kids safe from too much radiation.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10884916

• Understanding and treating headaches after concussions

  This study is looking at headaches that can happen after a concussion, trying to figure out why some people have ongoing pain and how we might be able to help them feel better.

  NIH research University of Arizona · Tucson, United States · NIH-10874748

• Investigating how sleep disruption after mild traumatic brain injury affects chronic headaches.

  This study is looking at how sleep problems might be linked to chronic headaches that some people get after a mild brain injury, and it will test if a medication called prazosin can help improve sleep and reduce headache pain.

  NIH research Seattle Inst for Biomedical/clinical Res · Seattle, United States · NIH-10872224

• Creating new treatments for headaches caused by medication overuse

  This study is looking for new medications to help people who get headaches from using migraine treatments too often, by blocking a specific substance in the brain that contributes to these headaches, so they can find relief without having to stop their current medications and deal with withdrawal.

  NIH research Washington University · Saint Louis, United States · NIH-10864662

• Investigating light sensitivity and pupil response in headaches after trauma

  This study is looking at how sensitivity to light and how your pupils react can help us understand headaches that happen after a concussion, and it’s for people who experience these headaches to help improve their diagnosis and treatment.

  NIH research University of Utah · Salt Lake City, United States · NIH-10814234

• Understanding how brain and protective membranes interact during migraine headaches

  This study is looking at how the brain and its protective layers work together during migraine headaches to help find new ways to relieve the pain for people who suffer from them.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-10745316

• Finding new targets to treat headaches after brain injuries

  This study is looking at the causes of post-traumatic headaches that many people get after a mild brain injury, and it's trying to find new ways to help treat these headaches with fewer side effects.

  NIH research Washington University · Saint Louis, United States · NIH-10685784

Related topics

Quick answers

How many Headache clinical trials are recruiting right now?

27, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (19 trials), China (2 trials), Spain (2 trials), Egypt (1 trial), Belgium (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1: 1, Phase 3: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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