How puberty hormones affect headaches in transmasculine teens

Effect of pubertal hormones on Headache in Transmasculine Adolescents

NIH-funded research University of Colorado Denver · NIH-11023071

This study is looking at how taking testosterone affects headaches in transmasculine teens, hoping to find ways to help manage their headaches better.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of Colorado Denver NIH-funded
Lab location1 site (Aurora, UNITED STATES)
Project IDNIH-11023071 on NIH RePORTER

What this research studies

This research investigates the impact of gender-affirming hormone therapy with testosterone on headaches in transmasculine adolescents. By analyzing health records and conducting assessments, the study aims to understand how these hormones influence headache frequency and severity. Additionally, it will explore changes in brain structure and function related to hormone therapy. The goal is to provide insights that could lead to better headache management for this population.

Who could benefit from this research

Good fit: Ideal candidates for this research are transmasculine adolescents aged 12 to 20 who are undergoing or considering gender-affirming hormone therapy.

Not a fit: Patients who are not transmasculine or those outside the age range of 12 to 20 may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved treatment strategies for headaches in transmasculine adolescents.

How similar studies have performed: While the specific focus on transmasculine adolescents is novel, previous research has shown that hormonal changes can significantly affect headache patterns in adolescents.

Where this research is happening

Aurora, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.