Clinical trial Recruiting at 1 site Observational Ages 18 and up

Comparing headache characteristics in patients with different flexion-rotation test results

Official title: Differences in Headache Characteristics of a Subgroup of Cervicogenic Headache Patients With a Positive or Negative FRT: a Cross-sectional Comparison.

Run by University Ghent · NCT06134791 · Data updated 2026-11-12

This study is trying to see how headaches are different in people with cervicogenic headaches based on whether their flexion-rotation test results are positive or negative.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorUniversity Ghent
Academic / other
Locations1 site (Ghent, Oost-Vlaanderen)
StatusRecruiting
StartedJuly 1, 2023
Main results expectedDecember 2026
Study endsDecember 2026
Registry record updatedNovember 18, 2023
Trial IDNCT06134791 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older who have been diagnosed with cervicogenic headache and experience headaches at least once a week.

Probably not a fit

Patients with headaches not classified as cervicogenic or those with other underlying conditions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the differences in headache characteristics between cervicogenic headache patients who have a positive versus a negative flexion-rotation test at the C1-C2 level. By analyzing these differences, the study seeks to inform future treatment strategies and promote more individualized care for patients suffering from headaches. The flexion-rotation test is a clinical assessment that may reveal important insights into the relationship between cervical spine function and headache intensity. The findings could potentially enhance the understanding of cervicogenic headaches and guide therapeutic interventions.

Why it matters

Potential benefit: If successful, this study could lead to more tailored treatment options for patients with cervicogenic headaches.

How similar studies have gone: While this approach is based on established clinical tests, the specific comparison of headache characteristics based on flexion-rotation test results is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Diagnosis of cervicogenic headache according to the ICHD-3 criteria:

A. Any headache fulfilling criterion C B. Clinical and/or imaging evidence1 of a disorder or lesion within the cervical spine or soft tissues of the neck, known to be able to cause headache2

C. Evidence of causation demonstrated by at least two of the following:

* headache has developed in temporal relation to the onset of the cervical disorder or appearance of the lesion
* headache has significantly improved or resolved in parallel with improvement in or resolution of the cervical disorder or lesion
* cervical range of motion is reduced, and headache is made significantly worse by provocative manœuvres
* headache is abolished following diagnostic blockade of a cervical structure or its nerve supply D. Not better accounted for by another ICHD-3 diagnosis

Age: 18+ years Headache for at least 1 day/week for at least 3 months Limited mobility of the neck NPRS \> 3/10

Exclusion Criteria:

* Primary headache forms: migraine, TTH
* Other secondary headaches that do not comply with the ICDH-3 criteria for CH
* Whiplash or other traumatic incident in the past
* Pregnancy or given birth in the last year
* Previous head, neck or shoulder surgery
* Cervical radiculopathy complaints
* Receiving other treatments for headache or neck pain (physical therapy/ostheopathy/chiropraxie...) in the previous month

Where it's running

  • University Ghent - campus UZ Ghent - Rehabilitation Sciences B3
    Ghent, Oost-Vlaanderen, Belgium
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.