Condition

Headache Disorders clinical trials and research

• 11Clinical trials
• 3NIH research projects
• 7Countries

Newest Headache Disorders clinical trials

All recruiting trials (11)

• HEADS Registry: Headache, Ear, Auditory, Dizziness, and Sinus</n> Registry

  This registry tests whether collecting online symptom reports from adults in the U.S. with sinus, vestibular, ear, or headache symptoms can help improve diagnosis and treatment.

  Recruiting Association of Migraine Disorders · North Kingstown, Rhode Island · NCT07754266

• OCT in Neurological Practice: Use of Retinal Layers to Help Diagnose and Follow Neurological Diseases

  This study tests whether optical coherence tomography (OCT) of the retina can help in diagnosing and tracking multiple sclerosis, Alzheimer's, Parkinson's, migraines, and other headaches compared with healthy people.

  Recruiting IRCCS San Raffaele · Milan, Milano · NCT07720765

• Scalp block for headache after aneurysmal subarachnoid hemorrhage in ICU patients

  We are testing whether a levobupivacaine scalp block added to standard pain medicines can reduce severe headache in adults in the ICU after aneurysmal subarachnoid hemorrhage treated endovascularly.

  Recruiting Hamad Medical Corporation · Doha · NCT07307508

• Personality traits, thinking skills, and pain sensitivity in people with headache

  This project will see how personality, cognitive function, and central sensitization relate to pain severity, symptom change, and treatment adherence over six months in adults with chronic or episodic headache.

  Recruiting IRCCS Centro Neurolesi Bonino Pulejo · Messina, Sicily · NCT07268768

• New methods to test preventive migraine treatment

  This trial will test how the active medicine, placebo injections, and the information given about them affect symptoms in adults with chronic migraine.

  Recruiting at 2 sites University of Aarhus · Aarhus C, Denmark and 1 other locations · NCT07071506

• Aerobic exercise to improve sensory, muscle, and psychosocial symptoms in women with migraine

  This trial will test whether supervised aerobic exercise plus one pain neuroscience education session helps women aged 18–48 with migraine reduce disability and improve sensory, musculoskeletal, and psychosocial symptoms.

  Recruiting University of Sao Paulo · Ribeirão Preto, São Paulo · NCT06716489

• Limiting smartphone use to treat primary headaches

  This study is testing if cutting back on smartphone use can help people with primary headaches feel better and need less medication.

  Recruiting All India Institute of Medical Sciences · New Delhi, National Capital Territory of Delhi · NCT06041997

• Comparing telehealth cognitive behavioral therapy for youth with migraines

  This study is testing whether online therapy for kids and teens with migraines works better when combined with medication or on its own.

  Recruiting at 15 sites Children's Hospital Medical Center, Cincinnati · Birmingham, Alabama and 14 other locations · NCT05889624

• Evaluating a lifestyle intervention for chronic migraine management

  This study is testing a new lifestyle program to see if it can help people with chronic migraines feel better compared to a control group.

  Recruiting Mayo Clinic · Phoenix, Arizona · NCT05415020

• Using Idebenone to prevent migraines

  This study is testing if a new compound called idebenone can help prevent migraines in adults by seeing if it reduces the number of migraine attacks compared to a placebo.

  Recruiting Phase 3 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT04151472

• Registry of rare primary headaches in Italian headache centers

  This study is trying to gather information about rare primary headaches from patients at Italian headache centers to better understand how common they are and how they affect people.

  Recruiting University of Florence · Florence · NCT03416114

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Non-Addictive Nose Spray Nerve Block for Quick Migraine Relief

  A new nasal nerve-blocking treatment being tested to relieve migraine attacks quickly without addictive drugs.

  NIH research Olfax, LLC · Asheville, United States · NIH-11405684

• NerveAI: smarter diagnosis and treatment planning for headache pain

  A new AI-assisted tool plus high-resolution MRI will help doctors diagnose occipital neuralgia more accurately and plan personalized treatments for people with headaches.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11347158

• Creating new treatments for headaches caused by medication overuse

  This study is looking for new medications to help people who get headaches from using migraine treatments too often, by blocking a specific substance in the brain that contributes to these headaches, so they can find relief without having to stop their current medications and deal with withdrawal.

  NIH research Washington University · Saint Louis, United States · NIH-10864662

Related topics

Quick answers

How many Headache Disorders clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (3 trials), Italy (3 trials), China (1 trial), Qatar (1 trial), India (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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