How the body's internal clock affects headache pain responses
Regulation of headache pain responses by the Trigeminal ganglion clock
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-11075791
This study is looking at how our body's internal clock affects pain, especially for people who suffer from headaches like migraines and cluster headaches, to find better ways to help manage their pain.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11075791 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the circadian clock in regulating pain responses, particularly in headache disorders like cluster headaches and migraines. By studying the trigeminal ganglion, which is crucial for headache pain signaling, the researchers aim to understand how biological rhythms influence pain sensitivity. They will use mouse models to explore the molecular mechanisms behind these rhythms and their impact on pain management strategies. The goal is to uncover new approaches to optimize treatment for patients suffering from severe headache disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic headache disorders, particularly cluster headaches and migraines.
Not a fit: Patients with headache disorders that do not exhibit circadian patterns or those with other unrelated pain conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that better manage headache pain by aligning therapies with the body's natural rhythms.
How similar studies have performed: Previous research has shown promising results in understanding the role of circadian rhythms in pain management, suggesting that this approach could yield significant insights.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YOO, SEUNG-HEE — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: YOO, SEUNG-HEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.