How the body's internal clock affects headache pain responses
Official title: Regulation of headache pain responses by the Trigeminal ganglion clock
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11075791 · Data updated 2026-11-12
This study is looking at how our body's internal clock affects pain, especially for people who suffer from headaches like migraines and cluster headaches, to find better ways to help manage their pain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | April 17, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $437,472 |
| NIH project number | 5R01NS136677-02 |
| Project ID | NIH-11075791 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic headache disorders, particularly cluster headaches and migraines.
✕Less likely to help
Patients with headache disorders that do not exhibit circadian patterns or those with other unrelated pain conditions may not benefit from this research.
What this research studies
This research investigates the role of the circadian clock in regulating pain responses, particularly in headache disorders like cluster headaches and migraines. By studying the trigeminal ganglion, which is crucial for headache pain signaling, the researchers aim to understand how biological rhythms influence pain sensitivity. They will use mouse models to explore the molecular mechanisms behind these rhythms and their impact on pain management strategies. The goal is to uncover new approaches to optimize treatment for patients suffering from severe headache disorders.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that better manage headache pain by aligning therapies with the body's natural rhythms.
How similar studies have gone: Previous research has shown promising results in understanding the role of circadian rhythms in pain management, suggesting that this approach could yield significant insights.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Yoo, Seung-Hee — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Yoo, Seung-Hee
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.