Investigating headaches after concussions in young people
Official title: Trigeminovascular sensitization in post-traumatic headache: electrophysiologic and blood biomarkers in youth
Funded at Children's Hosp of Philadelphia · NIH-11127677 · Data updated 2026-11-12
This study is looking at how concussions can cause long-lasting headaches in kids and teens, and it hopes to find clues in the brain that can help doctors better treat these headaches and improve care for young patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $215,195 |
| NIH project number | 5K23NS124986-04 |
| Project ID | NIH-11127677 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and adolescents who have recently suffered a concussion and are experiencing headaches.
✕Less likely to help
Patients who do not have a history of concussion or who are not experiencing headaches may not benefit from this research.
What this research studies
This research focuses on understanding how concussions can lead to persistent headaches in children and adolescents. The study aims to identify specific biological markers and electrical activity in the brain that may indicate a higher risk for prolonged headaches following a concussion. By examining these factors, the research seeks to improve treatment strategies for post-traumatic headaches, which are common yet poorly understood. The ultimate goal is to enhance care for young patients suffering from these debilitating symptoms.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and treatment options for children experiencing headaches after concussions.
How similar studies have gone: Previous research has shown promise in identifying biomarkers for migraine, suggesting that this approach may yield valuable insights into post-traumatic headaches as well.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Patterson Gentile, Carlyn Anne — Children's Hosp of Philadelphia
- Study coordinator: Patterson Gentile, Carlyn Anne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.