Understanding how brain and protective membranes interact during migraine headaches
Cortical-Meningeal Interactions Underlying Migraine Headache
This study is looking at how the brain and its protective layers work together during migraine headaches to help find new ways to relieve the pain for people who suffer from them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10745316 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between the brain's cortex and the protective membranes surrounding it, specifically focusing on how these interactions contribute to migraine headaches. By examining the trigeminal sensory system and its activation during migraine attacks, the study aims to uncover the underlying mechanisms that trigger these debilitating headaches. The approach includes analyzing neuronal activity and astrocyte signaling in both animal models and human subjects to identify potential new treatment targets for migraine relief.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who experience frequent migraines and have not found relief with existing treatments.
Not a fit: Patients who do not suffer from migraines or have other unrelated headache disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for migraine sufferers, improving their quality of life.
How similar studies have performed: Previous research has shown promising results in understanding migraine mechanisms, but this specific approach to studying cortical and meningeal interactions is relatively novel.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Levy, Dan — Beth Israel Deaconess Medical Center
- Study coordinator: Levy, Dan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.