Identifying who will develop long-lasting headaches after a concussion
Official title: Biomarker Signature to Predict the Persistence of Post-Traumatic Headache
Funded at Mayo Clinic Arizona · NIH-10897709 · Data updated 2026-11-12
This study is looking to find a way to predict which people might have long-lasting headaches after a concussion, so that doctors can start the right treatment sooner and help them feel better faster.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | September 1, 2019 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,038,506 |
| NIH project number | 5R33NS113315-03 |
| Project ID | NIH-10897709 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently experienced a concussion and are suffering from acute post-traumatic headache.
✕Less likely to help
Patients who have not experienced a concussion or those with chronic headache conditions unrelated to trauma may not benefit from this research.
What this research studies
This research aims to develop a biomarker signature that can predict which patients will experience persistent post-traumatic headache (PPTH) following a concussion. By analyzing clinical data and brain imaging, the study seeks to identify individuals at high risk for PPTH during the acute phase of their injury. This early identification could enable healthcare providers to initiate appropriate treatment sooner, potentially improving patient outcomes. The goal is to enhance decision-making for clinicians managing patients with acute post-traumatic headache.
Why it matters
Potential benefit: If successful, this research could lead to more effective early treatments for patients at risk of developing persistent headaches after a concussion.
How similar studies have gone: Previous research has shown promise in using biomarkers for predicting headache outcomes, but this specific approach is novel and untested.
Where this research is happening
-
Mayo Clinic Arizona
Scottsdale, United States Active
Researchers
- Principal investigator: Chong, Catherine Daniela — Mayo Clinic Arizona
- Study coordinator: Chong, Catherine Daniela
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.