Clinical trial Recruiting at 1 site Observational Ages 18 to 65

Thinking skills and how they relate to depression, anxiety, and work functioning

Official title: AtWork: The Relation Between Cognitive Functioning, Common Mental Disorders and Work Functioning

Run by Norwegian University of Science and Technology · NCT07349550 · Data updated 2026-11-12

This project will try metacognitive therapy with a work focus to see if it improves thinking skills and helps people with depression or anxiety who are at risk of sick leave return to work.

Quick facts

Study typeObservational
Ages18 Years to 65 Years
SexAll
Enrollment200 (estimated)
SponsorNorwegian University of Science and Technology
Academic / other
Locations1 site (Oslo)
StatusRecruiting
StartedJanuary 1, 2024
Main results expectedAugust 1, 2029
Study endsAugust 1, 2032
Registry record updatedJanuary 21, 2026
Trial IDNCT07349550 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults diagnosed with depression and/or anxiety who are at risk of sick leave and can attend outpatient treatment at the participating clinic are the ideal candidates.

Probably not a fit

People with cluster A or B personality disorders, ongoing substance abuse, psychosis, acute suicidality, or serious somatic illnesses are excluded and may not benefit from this specific program.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This naturalistic observational study follows outpatients with depression or anxiety who are at risk of sick leave as they receive metacognitive therapy combined with work-focused interventions at an ordinary clinic. Researchers measure cognitive functioning, symptoms, and work outcomes over time to see how changes in thinking skills relate to sick leave and return-to-work. The design is non-randomized and reflects routine clinical practice rather than a controlled intervention. Findings aim to identify whether impaired cognitive functioning predicts longer sick leave or poorer vocational recovery and whether cognitive function changes following therapy.

Why it matters

Potential benefit: If successful, the findings could help clinicians tailor treatment to improve cognitive functioning and support faster, more stable return-to-work for people with depression or anxiety.

How similar studies have gone: Metacognitive therapy has shown symptom benefits in other settings, but there are few or no prior studies specifically linking changes in cognitive functioning to return-to-work outcomes in depression or anxiety.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* diagnosis of depression and/or anxiety,
* at risk of sick leave

Exclusion Criteria:

* personality disorders cluster A or B,
* ongoing substance abuse,
* symptoms of psychosis,
* acute suicidality,
* serious somatic disorders

Where it's running

  • Diakonhjemmet hospital
    Oslo, Norway
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.