Precision treatment strategies for common mental disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on developing and applying precision treatment strategies for prevalent psychiatric conditions such as schizophrenia, major depressive disorder, and bipolar disorder. It utilizes pharmacogenomic insights tailored to the Chinese Han population to guide individualized medication selection. The approach includes quantitative assessments and therapeutic drug monitoring throughout the treatment process, aiming to create a systematic model for precision treatment in mental health. The study seeks to address the significant burden these disorders impose on individuals and society.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Schizophrenia: (1) Age 18-65 years, no gender restriction, Han ethnicity; (2) Diagnosis confirmed using the MINI-International Neuropsychiatric Interview (MINI) tool, meeting the DSM-5 criteria for schizophrenia; (3) Baseline Positive and Negative Syndrome Scale (PANSS) score ≥ 60; (4) Education level of middle school or higher, no language barriers, able to cooperate with assessment and treatment, and informed consent obtained from the patient or guardian.
* Depressive Disorder: (1) Age 18-65 years, no gender restriction, Han ethnicity; (2) Diagnosis confirmed using the MINI tool, meeting the DSM-5 criteria for depressive disorder; (3) Baseline Hamilton Depression Rating Scale (HAMD-17) score ≥ 17; (4) Education level of middle school or higher, no language barriers, able to cooperate with assessment and treatment, and informed consent obtained from the patient or guardian.
* Bipolar Disorder: (1) Age 18-65 years, no gender restriction, Han ethnicity; (2) Diagnosis confirmed using the MINI tool, meeting the DSM-5 criteria for manic or hypomanic episodes in bipolar disorder; (3) Baseline Young Mania Rating Scale (YMRS) score ≥ 13; (4) Education level of middle school or higher, no language barriers, able to cooperate with assessment and treatment, and informed consent obtained from the patient or guardian.

Exclusion Criteria:

* Patients with a history of or currently meeting the DSM-5 criteria for the following diagnoses: organic mental disorders, schizoaffective disorder, intellectual disability, dementia, other cognitive disorders, alcohol or drug dependence, and Axis II disorders including personality disorders;
* Patients with severe suicidal tendencies (as assessed by the MINI Chinese version suicide module with a moderate risk or higher), or those at risk of harming others;
* Patients with severe or unstable physical illnesses;
* Narrow-angle glaucoma;
* A history of epilepsy or seizures;
* Known pregnancy and/or breastfeeding, or those planning to become pregnant;
* Participation in another clinical trial, or unwilling or unable to complete the full course of this trial;
* Participants deemed unsuitable by the investigator.

Where it's running

• Peking University Sixth Hostipal
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Weihua Yue
• Email: dryue@bjmu.edu.cn
• Phone: 86-010-82805307

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.