Concurrent and consecutive rTMS plus CBM for depression in adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with major depressive disorder will receive either active or sham rTMS, and CBM-I will be delivered either concurrently with rTMS or in separate sessions. The trial will measure changes in depressive symptoms and negative interpretation bias, and explore brain changes in the dorsolateral prefrontal cortex. Neural and cognitive outcomes will be compared across delivery modes and between active versus sham stimulation. MRI feasibility will be considered to assess brain activity and cognitive control related to self-referential interpretation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18 years or above
* Right-handed
* Normal or corrected hearing and vision
* Obtained primary education or above
* Able to fluently read and understand Chinese
* Beck's Depression Inventory-II (BDI-II) score ranging from 14-28

Exclusion Criteria:

* History of severe physical disease, brain organic diseases, and neurological disorders (e.g., dementia, brain injury, stroke, epilepsy, Parkinson's disease)
* History of substance use/ dependence/ withdrawal
* Participants with intellectual disability based on IQ scores
* Participants with contraindications for rTMS such as foreign metal bodies, implant devices (cochlear implants) or history (personal or family) of seizure
* Participants who are not suitable to be scanned by magnetic resonance imaging (MRI) machine (e.g., claustrophobic, pregnant, metal in the body, hearing aids)

Where it's running

• InnoCentre of Clinical Neuropsychology, The University of Hong Kong
  Quarry Bay, Hong Kong Island, Hong Kong Recruiting

Study contacts

• Study coordinator: Richard Liu Mr. Liu
• Email: richliu18@connect.hku.hk
• Phone: +85290971398

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.