Condition
Late Life Depression (LLD) clinical trials and research
As of November 12, 2026, Find a Trial lists 5 Late Life Depression (LLD) clinical trials that are recruiting, at sites in 3 countries (most in United States (3), Canada (1), China (1)). By phase: Phase 1/2 (1), Phase 3 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 5Clinical trials
- 3Countries
Newest Late Life Depression (LLD) clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Risk-score predictor for dementia in older adults with depression | — | Nanchang, Jiangxi | Recruiting | Jun 30, 2026 |
| High-dose bilateral tDCS for older adults with late-life depression | Phase 1/2 | Dallas, Texas | Recruiting | Jun 18, 2026 |
| Lumateperone added to antidepressant therapy for older adults with treatment-resistant depression | Phase 3 | Tucson, Arizona and 1 other locations | Recruiting | Jun 3, 2026 |
| Accelerated versus once-daily theta-burst stimulation for late-life depression | — | Toronto, Ontario and 1 other locations | Recruiting | Mar 3, 2025 |
| Understanding cognitive decline in older adults with depression | — | San Francisco, California and 1 other locations | Recruiting | May 5, 2015 |
All recruiting trials (5)
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Risk-score predictor for dementia in older adults with depression
This study tests whether a point-based risk score from electronic medical records can accurately predict which older adults with depression will develop dementia.
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High-dose bilateral tDCS for older adults with late-life depression
This study tests whether high-dose, bilateral transcranial direct current stimulation can help people aged 60 or older with late-life depression who are on stable antidepressants.
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Lumateperone added to antidepressant therapy for older adults with treatment-resistant depression
A 10-week trial will test whether lumateperone helps reduce depression in people aged 60 and older who have not responded adequately to other antidepressants, compared with a placebo.
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Accelerated versus once-daily theta-burst stimulation for late-life depression
This test compares multiple theta-burst brain stimulation sessions per day to one session per day to see which better reduces symptoms in people 60 and older with moderate to severe treatment-resistant depression.
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Understanding cognitive decline in older adults with depression
This study is trying to understand how depression affects thinking and memory in older adults by looking at brain scans and comparing them to people without depression.
Related topics
Quick answers
How many Late Life Depression (LLD) clinical trials are recruiting right now?
5, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 3 countries. The most sites are in United States (3 trials), Canada (1 trial), China (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1/2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.