Longitudinal look at how lasting TMS benefits can be predicted for depression
Official title: Longitudinal Study on the Sustainability of Transcranial Magnetic Stimulation Protocols - Biomarkers
Run by Hospital Center Guillaume Régnier · NCT07684911 · Data updated 2026-11-12
This study follows people with major depressive disorder who responded to prior rTMS to see what factors predict how long their response lasts.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Hospital Center Guillaume Régnier Academic / other |
| Locations | 1 site (Rennes) |
| Status | Recruiting |
| Started | June 4, 2026 |
| Main results expected | February 2029 |
| Study ends | August 2029 |
| Registry record updated | July 6, 2026 |
| Trial ID | NCT07684911 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years or older with treatment-resistant unipolar or bipolar depression who previously responded to an rTMS course and can participate in MRI assessments and French-language questionnaires.
✕Probably not a fit
Patients who have not previously responded to rTMS or cannot complete MRI-based assessments may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to identify biomarkers and factors associated with the durability of response to repetitive transcranial magnetic stimulation (rTMS) in adults with unipolar or bipolar depression. Participants are adults who previously benefited from a course of high-frequency rTMS and will undergo ongoing assessments, potentially including MRI, to track response durability over time. There are specific inclusion criteria around prior response, language, and capacity to consent, with safety exclusions for active suicidality or unstable medical conditions. The study seeks to inform personalized treatment planning and resource allocation by elucidating predictors of long-term rTMS efficacy. No interventional therapies are assigned beyond standard rTMS practice within the observational framework.
Why it matters
Potential benefit: findings could help tailor future rTMS plans to individuals likely to maintain benefit over time.
How similar studies have gone: Earlier work suggests neurophysiological and imaging biomarkers may relate to rTMS response, but durable prediction remains an area of active research with limited validation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 or older. * Patients who have experienced treatment-resistant unipolar or bipolar depression and responded to a previous TMS course (response defined by a 50% reduction in MADRS score). * Sufficient command of French to complete questionnaires and follow instructions during MRI assessments and TMS treatments. * Willingness to comply with all study procedures, including availability for the duration of the study, and to communicate with study staff about adverse events and other clinically relevant information. * Patients who have expressed their informed written consent to participate in the study. * Person affiliated with a social welfare scheme or other scheme. Non-inclusion Criteria: * Current psychiatric comorbidity (suicidal risk, psychotic episode). * Unstable somatic pathology: active cancer, unstabilized endocrinological pathology, untreated sleep apnea. * For neuroimaging: Contraindications to magnetic resonance imaging (MRI) such as ferromagnetic metal in the body or severe claustrophobia * Adults under legal protection (legal guardianship, conservatorship, trusteeship), persons deprived of their liberty * Pregnancy or breast-feeding.
Where it's running
-
Centre Hospitalier Guillaume Régnier
Rennes, France Recruiting
Study contacts
- Study coordinator: Jean-Marie BATAIL
- Email: jm.batail@ch-guillaumeregnier.fr
- Phone: +332 99 33 39 37
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Digital twins to classify mental health patterns in adults with diabetes
This project will try to create 'digital twin' profiles that combine glucose, mood, and behavior data to track mental health patterns in adults with diabetes.
-
Right-sided low-frequency (1-Hz) rTMS versus left-sided intermittent theta-burst stimulation for depression
This trial will test whether right-sided low-frequency (1-Hz) rTMS works as well as left-sided iTBS for adults with unipolar or bipolar depression.
-
Understanding the impact of mood disorders and treatment responses
This study is trying to learn more about how people with depression and bipolar disorder respond to treatment by talking to them weekly for up to 12 weeks to improve future care and predict how well medications might work.
-
Bright Light Therapy for Depression
This study tests if Bright Light Therapy can help people with unipolar and bipolar depression feel better, and whether adding lifestyle changes can make it work even better.
-
Understanding how the orbitofrontal cortex guides approach vs. avoidance in depression
This study tests how different parts of the orbitofrontal cortex influence whether people pursue rewards or risk loss, and whether this pattern is altered in Major Depressive Disorder.
-
Health education program to help depression in older adults and caregivers in Ho Chi Minh City
A community-based education program for people 60+ and their caregivers is being tested to see if it can lower depression and improve quality of life compared with standard care.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.