Condition

Depression Disorder clinical trials and research

• 16Clinical trials
• 2NIH research projects
• 13Countries

Newest Depression Disorder clinical trials

All recruiting trials (16)

• Psychological prehabilitation for complex GI surgery

  A preoperative, structured psychological program called PREPARE-GI is tested to see if it helps adults with prior medical trauma undergoing complex GI surgery feel less stress, anxiety, and depression and recover better.

  Recruiting Northwestern University · Chicago, Illinois · NCT07865052

• Personalized TMS to Test Heart-Brain Linking in People with Depressive Tendencies

  This study tests whether individualized TMS guided by each person’s brain connections can influence heart-brain coupling in adults with depressive symptoms.

  Recruiting Xidian University · Xi'an, Shaanxi · NCT07753473

• Understanding how GIM residents’ well-being relates to their careers over time

  This study tests how burnout, depression, sleep problems, stress, and fatigue among general internal medicine residents relate to their future career paths.

  Recruiting at 3 sites University of Fribourg · Bern and 2 other locations · NCT07707453

• VOCALE LBD: Online Support for Caregivers of Lewy Body Dementia

  This online, text-based program tests whether a tailored 8-week caregiver group helps reduce depression in family caregivers of people with Lewy Body Dementia compared with standard educational materials.

  Recruiting University of Washington · Seattle, Washington · NCT07637097

• Music to improve health and coping for older adults in rural long-term care

  This project will try a 6-week music program with active activities like drumming to see if it reduces stress, anxiety, depression, and pain and helps adults living in two Flagstaff long-term care facilities cope better.

  Recruiting at 2 sites Northern Arizona University · Flagstaff, Arizona and 1 other locations · NCT07538427

• Aromatherapy to support mental health in women undergoing IVF

  This will test whether inhaling lavender oil twice daily can reduce anxiety, stress, and depression and improve quality of life for women awaiting IVF.

  Recruiting Federal University of Minas Gerais · Belo Horizonte, Minas Gerais · NCT07480668

• Virtual reality mindfulness added to usual esketamine care for hard-to-treat depression

  This will test whether adding a virtual-reality mindfulness program to usual esketamine treatment helps adults with treatment-resistant depression feel less depressed.

  Recruiting Hospital Universitari Vall d'Hebron Research Institute · Barcelona · NCT07422519

• GynMDD Add-On to Supportive Psychotherapy in Mild to Moderate Depression

  GynMDD is being tested as an add-on to supportive psychotherapy to see if it helps adults with mild to moderate depression feel better than psychotherapy with placebo.

  Recruiting Fondation FondaMental · Créteil · NCT07416747

• SoundHeal multi-sensory integrative therapy for detained youth with emotional dysregulation

  This program will test whether SoundHeal's multi-sensory therapy can help detained youth (ages 12–18) better manage emotional dysregulation, depression, anxiety, and stress.

  Recruiting SoundHeal · San Luis Obispo, California · NCT07364799

• Transcranial electrical stimulation for depression with chronic pain

  This trial tests whether active tACS or tDCS can help reduce pain in people with major depressive disorder and chronic pain, compared with a sham treatment.

  Recruiting at 2 sites Shanghai Mental Health Center · Shanghai, Shanghai Municipality and 1 other locations · NCT07334561

• Loneliness and depression in hospital care

  This project will see if loneliness changes how adults with depression improve during and after inpatient psychiatric treatment by using questionnaires, interviews, and blood, saliva, and stool samples.

  Recruiting Friedrich-Alexander-Universität Erlangen-Nürnberg · Erlangen, Bavaria and 1 other locations · NCT07333027

• Mixed nuts to support mood, stress, and thinking in young adults

  This trial will test whether eating a daily mix of nuts for six months helps improve mood, reduce anxiety and stress, and boost cognition and sleep in university students aged 18–25.

  Recruiting University of Castilla-La Mancha · Cuenca, Cuenca · NCT07292610

• Maintaining Regular Physical Activity After a Depressive Episode

  This study tests if organizational strategies and psychosocial skills help adults who had a depressive episode keep up regular physical activity after leaving rehab.

  Recruiting Hopital La Musse · Saint-Sébastien-de-Morsent · NCT07129928

• Two-week mindfulness or social-media reduction plus exercise program to improve college students' well-being

  This project will test whether daily 15-minute mindfulness meditations or cutting 30 minutes of social media and replacing that time with exercise for two weeks can reduce social media use and improve well-being in Johns Hopkins students who use social media more than an hour a day.

  Recruiting Johns Hopkins Bloomberg School of Public Health · Baltimore, Maryland · NCT07097545

• Heated yoga, sauna, or a mindfulness app for depression

  This project will test whether heated yoga, sauna sessions, or a mindfulness app reduce symptoms in adults with at least moderate depression.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07082998

• CYB003, a deuterated psilocin, for adults with major depressive disorder

  This trial will test whether adding CYB003 to a current antidepressant helps reduce symptoms in adults with major depressive disorder who have not responded well to their medication.

  Recruiting at 51 sites Phase 3 Cybin IRL Limited · Birmingham, Alabama and 78 other locations · NCT06793397

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding immune dysfunction and social stress in veterans with depression

  A study in U.S. veterans with major depressive disorder looks at how stress-related immune changes may be linked to depression and heart health.

  NIH research James J Peters VA Medical Center · Bronx, United States · NIH-11518516

• Understanding how social stress affects immune function and depression in veterans

  This study is looking at how problems with the immune system might be connected to depression in veterans who have faced social stress, especially those who served in Afghanistan and Iraq, and it hopes to find new ways to help improve their treatment for depression and PTSD.

  NIH research James J Peters VA Medical Center · Bronx, United States · NIH-11262178

Related topics

Quick answers

How many Depression Disorder clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (7 trials), Spain (2 trials), China (2 trials), France (2 trials), Germany (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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