Condition

Treatment Resistant Depression (TRD) clinical trials and research

• 27Clinical trials
• 1NIH research projects
• 1New in 30 days
• 13Countries

Newest Treatment Resistant Depression (TRD) clinical trials

All recruiting trials (27)

• French Minds: a French, Multimodal Cohort Study of Severe Psychiatric Disorders and Healthy Controls

  This study tests whether people with mood, psychotic, or autism disorders can be grouped into more similar subtypes based on social withdrawal and anhedonia, across ages 15 to 60.

  Recruiting at 10 sites Fondation FondaMental · Besançon and 16 other locations · NCT07881016

• DHEA add-on to standard antidepressants for treatment-resistant depression

  This trial tests whether adding 100 mg/day of DHEA to patients’ current antidepressant treatment helps people with treatment-resistant depression feel better.

  Recruiting at 9 sites Phase 3 Charite University, Berlin, Germany · Berlin, State of Berlin and 8 other locations · NCT07843927

• One-Day cTBS Over the Precuneus and iTBS Over the Left PFC for Treatment-Resistant Depression

  This study tests whether a one-day accelerated TMS session targeting the precuneus or the left dorsolateral prefrontal cortex can reduce depressive symptoms in adults with treatment-resistant depression, compared with sham stimulation.

  Recruiting Mclean Hospital · Belmont, Massachusetts · NCT07758010

• Predicting Treatment Response in Psychiatric Disorders Using Biological Markers

  This study tests whether biological markers can predict which patients with psychiatric conditions will respond to treatment.

  Recruiting Centre Hospitalier St Anne · Paris · NCT07741981

• Cannabidiol Oil as an Add-on for Treatment-Resistant Major Depression

  This study tests whether full-spectrum CBD oil added to standard antidepressants can help adults with treatment-resistant major depression.

  Recruiting Phase 1/2 Universidade do Sul de Santa Catarina · Tubarão, Santa Catarina · NCT07696871

• Biomarker-guided antidepressant choice to see if rTMS or ketamine works best for you

  This study tests whether brain and behavior markers can help match people with major depression to either rTMS or ketamine to see which works better for them.

  Recruiting at 2 sites Phase 4 Weill Medical College of Cornell University · New York, New York and 1 other locations · NCT07680140

• Response to Intermittent Theta Burst Stimulation in Treatment-Resistant Depression

  This study tests whether a four-week course of intermittent theta burst stimulation can help people with treatment-resistant depression by looking at symptoms, thinking skills, and blood biomarkers.

  Recruiting Gulhane Training and Research Hospital · Ankara, Ankara and 1 other locations · NCT07673913

• Lumateperone added to antidepressant therapy for older adults with treatment-resistant depression

  A 10-week trial will test whether lumateperone helps reduce depression in people aged 60 and older who have not responded adequately to other antidepressants, compared with a placebo.

  Recruiting at 2 sites Phase 3 Washington University School of Medicine · Tucson, Arizona and 1 other locations · NCT07623135

• Accelerated bilateral DMPFC iTBS for major depression

  This study tests whether a fast, multiple-daily session brain stimulation approach can help adults with major depressive disorder who have not fully benefited from standard antidepressants.

  Recruiting Istanbul University - Cerrahpasa · Istanbul · NCT07603804

• Psychedelic coaching added to ketamine treatment for treatment-resistant depression

  This trial will test whether adding psychedelic integration coaching to ongoing ketamine or esketamine maintenance helps people with treatment-resistant depression.

  Recruiting at 2 sites Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT07563868

• ALTO-207 for adults with treatment-resistant depression

  This trial will test whether ALTO-207 reduces depressive symptoms more than placebo in adults whose depression has not improved after at least two antidepressant treatments.

  Recruiting at 40 sites Phase 2 Alto Neuroscience · Dothan, Alabama and 62 other locations · NCT07553637

• Near-infrared brain light for somatic symptoms in treatment-resistant depression

  This will test whether twice-weekly near‑infrared transcranial photobiomodulation at 10 Hz or 40 Hz can reduce depressive and physical (somatic) symptoms in people with treatment‑resistant depression who are already on antidepressants.

  Recruiting Taipei Veterans General Hospital, Taiwan · Taipei · NCT07543328

• Ketogenic Diet with Accelerated Brain Stimulation for Treatment‑Resistant Depression

  This study tests whether adding a ketogenic diet to a personalized accelerated brain stimulation treatment helps reduce depression symptoms in adults with treatment‑resistant depression.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07376018

• Esketamine with preparation and integration therapy for treatment-resistant depression

  This study will test whether adding brief preparation and follow-up integration therapy to FDA-approved esketamine nasal spray helps adults with treatment-resistant depression feel better and keep improving longer.

  Recruiting at 2 sites Phase 4 University of Puerto Rico · San Juan and 1 other locations · NCT07369102

• Electroconvulsive therapy combined with transcranial magnetic stimulation for treatment-resistant depression

  This will test whether giving a short burst of intermittent theta-burst magnetic stimulation (iTBS) just before electroconvulsive therapy helps adults with treatment-resistant major depressive disorder by lowering the energy needed to trigger a therapeutic seizure.

  Recruiting Charles University, Czech Republic · Prague, Czech · NCT07324070

• Accelerated intermittent vs continuous theta-burst stimulation for treatment-resistant depression

  This trial will test whether two accelerated theta-burst magnetic stimulation approaches—intermittent (iTBS) and continuous (cTBS)—work better for adults with treatment-resistant depression.

  Recruiting Ataturk University · Erzurum · NCT07264452

• Rapid, robot-guided TMS with NRX-101 for treatment-resistant depression

  This trial tests whether a single-day, robot-guided brain stimulation plus NRX-101 can help adults with treatment-resistant depression compare to sham stimulation and placebo.

  Recruiting at 3 sites Phase 2/3 NeuroRx, Inc. · Sarasota, Florida and 2 other locations · NCT07227103

• At-home spaced transcranial direct current stimulation for treatment-resistant depression

  This will test whether a two-week program of at-home spaced transcranial direct current stimulation (tDCS) can help people with treatment-resistant depression who have not improved on antidepressants.

  Recruiting University of California, San Diego · San Diego, California · NCT07217223

• Psilocybin and trazodone in treatment-resistant depression

  This study tests whether adding trazodone to psilocybin helps people with treatment-resistant depression see benefit with different trazodone doses.

  Recruiting Phase 2 Centre Hospitalier St Anne · Paris · NCT07210112

• Esketamine nasal spray for people with treatment-resistant depression in routine care

  This study will try esketamine nasal spray in adults with treatment-resistant depression to see how well it works and how safe it is in everyday clinical settings.

  Recruiting at 5 sites Universita degli Studi di Genova · Genova, Ge and 4 other locations · NCT07146503

• Focused ultrasound neuromodulation for treatment-resistant depression

  This trial will test whether MRI-guided focused ultrasound using the Next Generation Dome Helmet can safely reduce depressive symptoms in adults whose depression has not improved with standard treatments.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07094789

• Algorithm-guided treatment versus usual care for treatment-resistant depression

  This test will see if a stepwise, algorithm-guided plan for antidepressant treatment helps adults (18–65) with treatment-resistant unipolar depression reduce symptoms more than usual clinician-directed care over 12 weeks.

  Recruiting Phase 4 Aalborg University Hospital · Aalborg · NCT07080723

• Transcranial stimulation for treatment-resistant depression with high inflammation

  This study is testing if a type of brain stimulation can help young adults with treatment-resistant depression and high inflammation feel better.

  Recruiting Tianjin Anding Hospital · Tianjin, Tianjin Municipality · NCT06812923

• Personalized deep brain stimulation for treating depression

  This study is testing a personalized deep brain stimulation treatment for people with depression that doesn't improve with other therapies to see if it can help them feel better.

  Recruiting Early Phase 1 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06784388

• Exercise priming before rTMS (iTBS) for difficult-to-treat depression

  This will test whether adding a 4-week structured exercise program before and during intermittent theta-burst stimulation (iTBS) helps physically inactive adults with treatment-resistant depression feel better.

  Recruiting The Royal Ottawa Mental Health Centre · Ottawa, Ontario · NCT06773949

• Using intravenous ketamine to treat severe depression that hasn't responded to other treatments

  This study is testing if intravenous ketamine can help adults with severe depression that hasn't improved with other treatments feel better.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT06668571

• Vagus Nerve Stimulation for Treatment Resistant Depression

  This study is testing if Vagus Nerve Stimulation can help adults with treatment-resistant depression feel better when combined with their current medications.

  Recruiting at 14 sites Assistance Publique - Hôpitaux de Paris · Angers, France and 23 other locations · NCT05952674

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Multi-site psilocybin trial for treatment-resistant depression in Veterans

  A large, multi-site study is testing whether psilocybin can help Veterans with hard-to-treat depression, with or without PTSD.

  NIH research Birmingham VA Medical Center · Birmingham, United States · NIH-11298677

Related topics

Quick answers

How many Treatment Resistant Depression (TRD) clinical trials are recruiting right now?

27, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (8 trials), France (4 trials), Canada (3 trials), Turkey (Türkiye) (3 trials), China (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Phase 2: 3, Phase 3: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →