Understanding risk factors for cognitive problems in people with coronary heart disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational study enrolling about 2,352 adults with coronary heart disease at Beijing Anzhen Hospital. Participants undergo comprehensive cognitive testing, metabolic labs, and multimodal imaging (CCTA, cardiac MRI) plus sleep, frailty, and psychological assessments. The main goal is to identify risk factors associated with cognitive impairment and to explore possible mechanisms linking heart disease to brain function. Findings may help with early identification and personalized approaches to prevent or mitigate cognitive decline in CHD patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥ 18 years
2. Diagnosis of coronary heart disease (meeting at least one of the following):

   * Coronary angiography or coronary CTA showing ≥50% stenosis in ≥1 major coronary artery;
   * Established diagnosis of coronary heart disease with prior medical, interventional, or surgical treatment;
   * Objective evidence of myocardial ischemia or typical clinical symptoms
3. Completion of standardized neuropsychological assessment during hospitalization
4. Completion of metabolic marker evaluation (fasting glucose, insulin, HbA1c, etc.) and agreement to undergo relevant imaging and functional assessments
5. Provision of signed written informed consent

Exclusion Criteria:

1. Previously diagnosed dementia.
2. History of stroke, cerebral hemorrhage, or other central nervous system diseases known to cause cognitive impairment.
3. Severe psychiatric disorders (e.g., schizophrenia, bipolar disorder).
4. Pregnancy or breastfeeding.

Where it's running

• Beijing Anzhen Hospital
  Beijing, China, China Recruiting

Study contacts

• Study coordinator: Chenchen Tu, Chief Physician
• Email: tcc2033@163.com
• Phone: 15201648899

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.