Metals and Heart Disease in Different Communities
Exposure to Metal-Mixtures and Coronary Heart Disease Across Diverse Populations
['FUNDING_R01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11196717
This project looks at how exposure to different metals might affect heart health in various groups of people.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11196717 on ClinicalTrials.gov |
What this research studies
Coronary heart disease is a major health concern worldwide, and we know that exposure to toxic metals like arsenic can be a risk factor. However, people are often exposed to many metals at once, and their combined effects on heart health are not well understood. This project will explore how mixtures of metals, and how our genes interact with these exposures, contribute to heart disease risk. Our goal is to identify specific combinations of metals and genetic factors that put certain groups at higher risk, especially within diverse populations.
Who could benefit from this research
Good fit: This project focuses on understanding risk factors in diverse adult populations, including American Indian, Black American, and Bangladeshi individuals, who are 21 years or older.
Not a fit: Patients already diagnosed with coronary heart disease may not directly benefit from this specific project, as it focuses on identifying risk factors rather than treatment.
Why it matters
Potential benefit: If successful, this work could help identify specific environmental and genetic risk factors for coronary heart disease, leading to better prevention strategies for at-risk populations.
How similar studies have performed: While individual metal exposures have been linked to heart disease, large-scale studies on metal mixtures and gene-metal interactions in diverse populations are largely new.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, YU — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: CHEN, YU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Candidate Disease Gene