Glycocalyx and oxidative stress in blood vessel lining during coronary bypass surgery
Official title: The Role of Glycocalyx and Oxidative Stress in Endothelial Function (Part 2)
Run by Josip Juraj Strossmayer University of Osijek · NCT07451873 · Data updated 2026-11-12
This project will see if changes in the endothelial glycocalyx and oxidative stress markers relate to microvascular function and outcomes in adults having elective coronary artery bypass grafting.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 35 (estimated) |
| Sponsor | Josip Juraj Strossmayer University of Osijek Academic / other |
| Locations | 1 site (Osijek) |
| Status | Recruiting |
| Started | October 1, 2025 |
| Main results expected | September 30, 2029 |
| Study ends | September 30, 2029 |
| Registry record updated | March 9, 2026 |
| Trial ID | NCT07451873 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 of Caucasian background who are scheduled for elective coronary artery bypass grafting at the study site and can give informed consent.
✕Probably not a fit
Patients undergoing emergency surgery or those with sepsis, severe renal or hepatic failure, immunosuppression, active cancer, or therapies that markedly alter oxidative stress (e.g., high-dose corticosteroids) are excluded and likely will not benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational study will measure endothelial glycocalyx thickness and markers of oxidative stress and inflammation in adults undergoing elective coronary artery bypass grafting, collecting samples before and after surgery. Researchers will test microvascular reactivity using bypass graft tissue in in vitro experiments and quantify soluble glycocalyx fragments, oxidative stress markers, and antioxidant capacity from serum and PBMCs. Functional vascular tests and biomarker results will be correlated with clinical outcomes and graft performance to identify associations. The work is carried out at Osijek University Hospital as part of a program to increase interdisciplinary cardiovascular research capacity.
Why it matters
Potential benefit: If successful, the study could identify biomarkers and mechanisms that help predict graft function and postoperative outcomes after CABG.
How similar studies have gone: Previous research has linked glycocalyx degradation and oxidative stress to endothelial dysfunction, but applying these measures to predict graft reactivity and CABG outcomes is relatively novel and not yet widely validated.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult patients of both sexes over 18 years of age * Caucasian * undergoing elective coronary artery bypass grafting (CABG) * provided written informed consent Exclusion Criteria: * emergency surgery * sepsis or severe systemic inflammation before surgery * severe renal or hepatic insufficiency * immunosuppression * serious comorbidities (e.g., active cancer) * therapies that could affect oxidative stress (e.g., high doses of corticosteroids)
Where it's running
-
Osijek University Hospital
Osijek, Croatia Recruiting
Study contacts
- Study coordinator: Ines Drenjančević, MD, PhD
- Email: ines.drenjancevic@mefos.hr
- Phone: +385912241406
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.