How exposure to mixtures of toxic metals affects heart disease risk
Official title: Exposure to Metal-Mixtures and Coronary Heart Disease Across Diverse Populations
Funded at New York University School of Medicine · NIH-10821725 · Data updated 2026-11-12
This study is looking at how being around certain toxic metals, like arsenic, might affect your heart health, especially for people who may be more at risk for heart disease, and it aims to find out if being exposed to a mix of these metals is different from just being exposed to one at a time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 24, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $740,365 |
| NIH project number | 1R01ES035219-01A1 |
| Project ID | NIH-10821725 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals over 21 years old who have been exposed to toxic metals, particularly those from diverse populations such as American Indians and Black Americans.
✕Less likely to help
Patients who have no history of exposure to toxic metals or who do not have risk factors for coronary heart disease may not benefit from this research.
What this research studies
This research investigates the relationship between exposure to various toxic metals, including inorganic arsenic, and the risk of developing coronary heart disease (CHD). It aims to understand how combinations of these metals may have different effects on heart health compared to individual exposures. By analyzing genetic factors alongside environmental exposures, the study seeks to identify specific population groups that may be at higher risk for CHD due to these metal mixtures. The research will utilize large epidemiological data to provide a comprehensive view of these interactions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention strategies for coronary heart disease, particularly in populations at higher risk due to metal exposure.
How similar studies have gone: While there have been limited studies on individual metal exposures, this research is novel in its focus on the combined effects of metal mixtures and genetic interactions on coronary heart disease.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Chen, Yu — New York University School of Medicine
- Study coordinator: Chen, Yu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.