NMR-based Risk Test and Digital Health Support for midlife adults in Eloisa
Official title: Effectiveness and Cost-Effectiveness of NMR Metabolomics-Based Risk Assessment and Stratified Preventive Digital and Guideline-Directed Interventions in a Middle-Aged Population: A Population Cohort Study With an Embedded Pragmatic Randomised Trial and Health Economic Evaluation
Run by University of Eastern Finland · NCT07820800 · Data updated 2026-11-12
This study tests whether an NMR metabolomics risk test can guide tailored digital health programs for midlife adults at risk of diabetes, heart disease, stroke, kidney disease, or fatty liver.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 45 Years to 55 Years |
| Sex | All |
| Enrollment | 1400 (estimated) |
| Sponsor | University of Eastern Finland Academic / other |
| Locations | 1 site (Savonlinna) |
| Status | Recruiting |
| Started | September 2026 |
| Main results expected | September 2027 |
| Study ends | March 2028 |
| Registry record updated | October 6, 2026 |
| Trial ID | NCT07820800 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are 45, 50, or 55 in 2026, residents of the Eloisa region, who have an interpretable NMR metabolomics risk result and can use a digital device.
✕Probably not a fit
Low-risk individuals may receive risk information and general guidance but are not randomized to digital interventions.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The PREMAP study uses a blood-based NMR metabolomics risk assessment to categorize adults aged 45, 50, or 55 in the Eloisa region of Finland into low, moderate, or high multi-disease risk. All participants are followed in a population cohort, while those with moderate or high risk are randomized to one of three digital lifestyle interventions for up to 12 months, with a fourth arm for high-risk individuals receiving physician consultation and therapy optimization. Interventions include a habit-based app (BitHabit), a structured digital coaching program (Onnikka), and a guideline-based self-care pathway (Oma Eloisa). The study examines changes in multi-disease risk predictions and wellbeing at 6 months, alongside patient-reported outcomes and healthcare utilization. A non-randomized low-risk group provides a naturalistic reference for risk communication and general health information.
Why it matters
Potential benefit: If successful, participants at higher risk could see improved risk profiles and wellbeing through personalized digital support and medical optimization.
How similar studies have gone: Previous work has shown digital health interventions can improve lifestyle and risk factors, though this pragmatic, metabolomics-stratified randomization in a real-world public sector setting is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Permanent resident of the Eloisa Wellbeing Services County (South Savo, Finland), or has selected Eloisa primary health care as their primary public care provider * Turning 45, 50, or 55 years of age during calendar year 2026 * NMR metabolomics-based risk assessment result classified as low, moderate, or high multi-disease risk * Able to provide written informed consent digitally * Able to use a smartphone, tablet, or computer for digital application access * Resident of Finland with a Finnish personal identity code (required for health register linkage) Exclusion Criteria: * Currently pregnant or breastfeeding * Incarcerated or under forensic psychiatric care * Significantly impaired capacity for self-determination * Insufficient proficiency in Finnish to provide informed consent and complete study procedures * No Finnish personal identity code
Where it's running
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Wellbeing Services County of South Savo (Eloisa) (provide social and healthcare services and emergency services in the Enonkoski, Hirvensalmi, Juva, Kangasniemi, Mikkeli, Mäntyharju, Pieksämäki, Puumala, Rantasalmi, Savonlinna ja Sulkava)
Savonlinna, Finland Recruiting
Study contacts
- Study coordinator: Janne Martikainen, PhD, Professor
- Email: janne.martikainen@uef.fi
- Phone: +3583552600
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.