Research on heart and kidney disease interactions
Official title: Research on Optimal Diagnosis and Treatment of Cardiorenal Syndrome
Run by Nanjing First Hospital, Nanjing Medical University · NCT05397392 · Data updated 2026-11-12
This study looks at how heart and kidney problems affect each other to find better treatment options for people with cardiorenal syndrome.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1200 (estimated) |
| Sponsor | Nanjing First Hospital, Nanjing Medical University Academic / other |
| Locations | 1 site (Nanjing) |
| Status | Recruiting |
| Started | January 2016 |
| Main results expected | December 2026 |
| Study ends | December 2027 |
| Registry record updated | June 2, 2022 |
| Trial ID | NCT05397392 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients diagnosed with various types of cardiorenal syndrome as per KDIGO and ADQI classification standards.
✕Probably not a fit
Patients who are pregnant, breastfeeding, or unable to adhere to follow-up treatment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to estimate the characteristics, pathogenesis, risk factors, and intervention measures for various stages of heart and kidney diseases, collectively known as cardiorenal syndrome. It focuses on understanding the complex interplay between heart and kidney dysfunction, which can occur acutely or chronically. By systematically observing patients diagnosed with different types of cardiorenal syndrome, the study seeks to optimize treatment strategies based on the specific needs of these patients. The research is particularly relevant given the rising incidence of cardiorenal syndrome in China and the lack of targeted studies in this area.
Why it matters
Potential benefit: If successful, this study could lead to more effective treatment strategies for patients suffering from cardiorenal syndrome.
How similar studies have gone: While there is limited research specifically targeting cardiorenal syndrome, similar observational studies have shown promise in understanding complex disease interactions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients meet the diagnosis of various types of cardiorenal syndrome according to the classification standards of various types formulated by KDIGO and ADQI expert consensus. Different syndromes were identified and classified into five subtypes. Acute CRS (type 1): acute worsening of heart function (AHF-ACS) leading to kidney injury and/or dysfunction. Chronic cardio-renal syndrome (type 2): chronic abnormalities in heart function (CHF-CHD) leading to kidney injury and/or dysfunction. Acute reno-cardiac syndrome (type 3): acute worsening of kidney function (AKI) leading to heart injury and/or dysfunction. Chronic reno-cardiac syndrome (type 4): chronic kidney disease leading to heart injury, disease, and/or dysfunction. Secondary CRS (type 5): systemic conditions leading to simultaneous injury and/or dysfunction of heart and kidney. Exclusion Criteria: Pregnant or breastfeeding women; Female patients with recent birth plans; Patients who cannot follow up on medications.
Where it's running
- Nanjing, China Recruiting
Study contacts
- Study coordinator: Yue Zhou, master of medicine
- Email: 56005460@qq.com
- Phone: +8615380998793
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.