Research on heart and kidney disease interactions
Research on Optimal Diagnosis and Treatment of Cardiorenal Syndrome
This study looks at how heart and kidney problems affect each other to find better treatment options for people with cardiorenal syndrome.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Nanjing First Hospital, Nanjing Medical University Academic / other |
| Locations | 1 site (Nanjing) |
| Trial ID | NCT05397392 on ClinicalTrials.gov |
What this trial studies
This observational study aims to estimate the characteristics, pathogenesis, risk factors, and intervention measures for various stages of heart and kidney diseases, collectively known as cardiorenal syndrome. It focuses on understanding the complex interplay between heart and kidney dysfunction, which can occur acutely or chronically. By systematically observing patients diagnosed with different types of cardiorenal syndrome, the study seeks to optimize treatment strategies based on the specific needs of these patients. The research is particularly relevant given the rising incidence of cardiorenal syndrome in China and the lack of targeted studies in this area.
Who should consider this trial
Good fit: Ideal candidates include patients diagnosed with various types of cardiorenal syndrome as per KDIGO and ADQI classification standards.
Not a fit: Patients who are pregnant, breastfeeding, or unable to adhere to follow-up treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective treatment strategies for patients suffering from cardiorenal syndrome.
How similar studies have performed: While there is limited research specifically targeting cardiorenal syndrome, similar observational studies have shown promise in understanding complex disease interactions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients meet the diagnosis of various types of cardiorenal syndrome according to the classification standards of various types formulated by KDIGO and ADQI expert consensus. Different syndromes were identified and classified into five subtypes. Acute CRS (type 1): acute worsening of heart function (AHF-ACS) leading to kidney injury and/or dysfunction. Chronic cardio-renal syndrome (type 2): chronic abnormalities in heart function (CHF-CHD) leading to kidney injury and/or dysfunction. Acute reno-cardiac syndrome (type 3): acute worsening of kidney function (AKI) leading to heart injury and/or dysfunction. Chronic reno-cardiac syndrome (type 4): chronic kidney disease leading to heart injury, disease, and/or dysfunction. Secondary CRS (type 5): systemic conditions leading to simultaneous injury and/or dysfunction of heart and kidney. Exclusion Criteria: Pregnant or breastfeeding women; Female patients with recent birth plans; Patients who cannot follow up on medications.
Where this trial is running
Nanjing
- Nanjing, China (Recruiting)
Study contacts
- Study coordinator: Yue Zhou, master of medicine
- Email: 56005460@qq.com
- Phone: +8615380998793
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.