Genetic clues to blood fats and heart disease progression
Official title: Using genetic variation to study biology of blood lipids & coronary heart disease
Funded at Boston University Medical Campus · NIH-11293111 · Data updated 2026-11-12
Researchers are studying how genetic differences affect blood lipid levels and heart disease risk so doctors can tailor prevention for people at different ages.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2015 |
| Project end | April 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $832,931 |
| NIH project number | 2R01HL127564-09 |
| Project ID | NIH-11293111 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults across a wide age range, especially young adults (18-40) and individuals at risk for or with a history of CHD.
✕Less likely to help
Patients without access to genetic testing or those not at risk for lipid-related CHD may see limited direct benefit.
What this research studies
This project uses a large, collaborative dataset to map how genes influence lipid levels and coronary heart disease across ages. It will search for age-specific genetic variants, explore progression and recurrence, and develop a polygenic score to help prevent CHD in young adults. The work will rely on genome-wide analyses and careful data sharing among researchers to translate findings into clinical practice. If successful, it could lead to better risk prediction and personalized prevention strategies for heart disease.
Why it matters
Potential benefit: If successful, patients could receive more accurate risk predictions and personalized prevention plans based on their genetic profile.
How similar studies have gone: Previous GLGC work has shown that lipid genetics can inform risk, and this renewal aims to refine and expand those insights.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Peloso, Gina Marie — Boston University Medical Campus
- Study coordinator: Peloso, Gina Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.