Yiyang Huoluo Decoction for coronary heart disease with atherosclerosis in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 1/2 interventional study compares standard Western medical therapy alone versus standard therapy plus Yiyang Huoluo Decoction in older adults with stable angina and coronary atherosclerosis. Participants aged 50–75 with CCS class I–III angina and prior drug-eluting stent implantation will be enrolled and assigned to one of two treatment groups. Researchers will monitor safety alongside clinical outcomes such as angina symptoms, cardiac-related measures, and laboratory or cellular markers of vascular health and repair. The trial aims to characterize tolerability when combined with routine heart medications and to provide preliminary signals of benefit.

Why it matters

Who can join: the full rules

Inclusion Criteria:

All of the following conditions must be met simultaneously for enrollment:

* ① Meet the diagnostic criteria for stable angina pectoris;
* ② Classified as Grade I to III according to the Canadian Cardiovascular Society (CCS) Angina Grading Scale;
* ③ Meet the diagnostic criteria for chest discomfort syndrome due to yang qi deficiency and decline (a traditional Chinese medicine pattern differentiation);
* ④ Aged between 50 and 75 years old;
* ⑤ Received drug-eluting stent implantation due to severe vascular stenosis (single artery ≥75%， or LM ≥50%) detected by coronary angiography;
* ⑥ Able to actively comply with medical instructions and voluntarily sign the written informed consent form.

Exclusion Criteria:

Participants will be excluded if they meet any of the following conditions:

* ① Diagnosed with acute coronary syndrome (including acute ST-segment elevation myocardial infarction, acute non-ST-segment elevation myocardial infarction, and unstable angina pectoris) after relevant examinations;
* ② Suffer from chest pain caused by non-cardiac diseases other than stable angina pectoris; or have complicated severe hypertension (systolic blood pressure ≥ 180mmHg and/or diastolic blood pressure ≥ 110mmHg), severe cardiopulmonary insufficiency, or malignant tumor;
* ③ Have severe endocrine, hematological or rheumatic immune system diseases, severe hepatic and renal dysfunction, active gastrointestinal bleeding, or mental illness;
* ④ Have an allergic constitution or a history of allergic reactions to traditional Chinese medicine;
* ⑤ Have incomplete major baseline data that may affect the trial results, or have participated in other clinical trials recently.

Where it's running

• People's Hospital of Anji
  Huzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Liang Xia, Doctor
• Email: 407928215@qq.com
• Phone: 86-15057172609

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Prospective cardiac surgery cohort to improve perioperative care

  A multi-center study will test a large, forward-looking database of adults undergoing heart surgery to better understand what affects short- and long-term outcomes.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07662317

• Sivelestat sodium treatment after off-pump coronary artery bypass grafting (OPCABG)

  This trial will test whether giving sivelestat sodium after off-pump coronary bypass surgery helps protect the heart and reduce inflammation in adults having OPCABG.

  Recruiting Phase 2 Affiliated Hospital of Nantong University · Nantong, Jiangsu · NCT07118930

• Drug-coated balloon treatment versus medication for fat-rich coronary plaques

  This trial will test whether using a paclitaxel-coated balloon during PCI can reduce the fat content of dangerous coronary plaques in adults with acute coronary syndrome compared with standard medication alone.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT07107971

• μFR-guided Drug-Coated Balloon Angioplasty vs Angiography-guided Angioplasty in Coronary Artery Disease

  This trial tests whether using computational μFR guidance during drug-coated balloon angioplasty is better than standard angiography guidance for people with de novo coronary artery lesions.

  Recruiting Centro Cardiologico Monzino · Cosenza, CS and 3 other locations · NCT07917234

• Gastric Ultrasound Before CABG to See if Heart Function Changes Stomach Contents

  This study checks whether people with weaker heart function before elective CABG have different stomach contents seen on ultrasound.

  Recruiting Adiyaman University · Adıyaman · NCT07898215

• Can preoperative photon-counting CT help predict heart recovery after bypass surgery?

  This observational study tests whether a preoperative photon-counting CT can help predict heart function 3 months after coronary bypass surgery in adults with coronary artery disease.

  Recruiting Chinese PLA General Hospital · Beijing · NCT07883499

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.