Investigating how environmental pollutants affect heart disease risk
Per- and polyfluoroalkyl substances, apolipoproteins, and risk of coronary heart disease
This study is looking at how certain chemicals found in the environment might affect heart health, specifically how they could influence cholesterol levels and increase the risk of heart disease, and it invites people to share their health information and blood samples to help with this important research.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11075864 on NIH RePORTER |
What this research studies
This research explores the relationship between per- and polyfluoroalkyl substances (PFAS) and the risk of coronary heart disease (CHD). It aims to understand how these environmental pollutants may disrupt the metabolism of specific lipoproteins associated with heart disease. By analyzing data from diverse U.S. cohorts, the study will conduct both cross-sectional and longitudinal investigations to clarify the connections between PFAS exposure, lipoprotein levels, and CHD risk. Patients may be asked to provide blood samples and health information to contribute to this important research.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from diverse ethnic backgrounds who may have been exposed to PFAS and are at risk for coronary heart disease.
Not a fit: Patients who have no exposure to PFAS or who do not have risk factors for coronary heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for coronary heart disease linked to environmental pollutants.
How similar studies have performed: Previous studies have shown associations between environmental pollutants and cardiovascular health, but this research aims to provide novel insights into specific mechanisms involving lipoproteins.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Sun, Qi — Brigham and Women's Hospital
- Study coordinator: Sun, Qi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.