Exploring the link between unstable angina and anxiety-depressive syndrome
Immunological Features of Unstable Angina Pectoris in Comorbidity With Anxiety-depressive Syndrome
Samarkand State Medical Institute · NCT04599621
This study looks at how unstable angina and anxiety or depression are connected in people with heart disease by checking their blood for certain markers.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3 (estimated) |
| Sex | All |
| Sponsor | Samarkand State Medical Institute (other) |
| Locations | 1 site (Samarkand) |
| Trial ID | NCT04599621 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between unstable angina pectoris and anxiety-depressive syndrome in patients with coronary artery disease. It includes 202 participants, with a focus on cytokine levels and uric acid in blood samples collected after fasting. The study employs established diagnostic criteria and scales to assess both physical and mental health aspects. The methodology involves detailed blood analysis using enzyme-linked immunosorbent assay (ELISA) to measure specific cytokines and uric acid levels.
Who should consider this trial
Good fit: Ideal candidates are patients diagnosed with unstable angina pectoris or stable exertional angina and who meet specific inclusion criteria.
Not a fit: Patients with acute conditions, severe mental health issues, or those who are pregnant or lactating may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the interplay between heart disease and mental health, leading to improved treatment strategies for affected patients.
How similar studies have performed: While the relationship between coronary heart disease and mental health has been explored, this specific observational approach focusing on cytokine levels in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * the presence of an established diagnosis in patients with coronary artery disease * unstable angina pectoris (NS). When making a diagnosis, the recommendations of ESH / ESC (2015) and RCO / WHO (2014) were used. * stable exertional angina (SSN) I-III FC. When making the diagnosis, the IHD classification was used, adopted at the IV Congress of Cardiologists of the Republic of Uzbekistan (2000), as well as in accordance with the recommendations of ESH / ESC (2019) and RCO / WHO (2017) Exclusion Criteria: * The patient's refusal to participate in the study; * Pregnancy and lactation; * Severe and unstable condition of the patient, making it difficult to conduct a questionnaire (for ethical reasons); * Acute violation of cerebral circulation; * History of acute or chronic psychosis; * The presence of concomitant acute diseases or chronic diseases in the acute stage. Throughout the study, all patients were assigned the right to voluntarily withdraw from the study at their own request, notifying the researcher in writing or orally.
Where this trial is running
Samarkand
- Zarina — Samarkand, Uzbekistan (RECRUITING)
Study contacts
- Study coordinator: Zarina Nasirova, PhD
- Email: zarina.nasirova.91@mail.ru
- Phone: +998902768950
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Coronary Heart Disease, unstable angina pectoris, uric acid, cytokine imbalance