Metal exposures and heart disease: how genes and mixtures shape risk
Official title: Exposure to Metal-Mixtures and Coronary Heart Disease Across Diverse Populations
Funded at New York University School of Medicine · NIH-11372279 · Data updated 2026-11-12
A large study from NYU aims to understand how exposure to arsenic and other metals, together with genetic factors, influence the risk of coronary heart disease in diverse adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 24, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $676,256 |
| NIH project number | 5R01ES035219-03 |
| Project ID | NIH-11372279 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older from diverse populations, including American Indian and Black American communities, who may have varying exposure to metals.
✕Less likely to help
People with no exposure to metal mixtures or no relevant genetic risk information may see limited direct benefit.
What this research studies
This project will look at how different metal exposures interact with a person’s genes to affect the chances of developing coronary heart disease. Researchers will analyze large groups of diverse adults to see which metal combinations are most risky and how genetic differences may change that risk. The study focuses on population-level data and gene-metal interactions to reveal who is most vulnerable. Results could guide personalized prevention strategies and public health actions.
Why it matters
Potential benefit: If successful, the findings could lead to targeted prevention and earlier detection for people with higher genetic or environmental risk.
How similar studies have gone: Previous studies on gene–environment interactions in CHD have been small; this study aims to scale up and broaden diversity.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Chen, Yu — New York University School of Medicine
- Study coordinator: Chen, Yu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.