CTCA before invasive angiography in people with prior CABG
Official title: A Multi-Centre, Randomised Trial Assessing the Value of Computed Tomography Coronary Angiography Prior to Invasive Coronary Angiography in Patients With Previous Coronary Artery Bypass Grafts in Reducing Cardiac Events
Run by Queen Mary University of London · NCT07165678 · Data updated 2026-11-12
This study tests whether a CTCA-guided plan before invasive angiography can reduce major heart-related events in people who had CABG and now have chest pain or a heart attack.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Queen Mary University of London Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (London) |
| Status | Recruiting |
| Started | April 16, 2026 |
| Main results expected | July 31, 2029 |
| Study ends | July 31, 2029 |
| Registry record updated | June 5, 2026 |
| Trial ID | NCT07165678 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with prior CABG presenting with angina or suspected ischemia who are indicated for coronary angiography and able to consent.
✕Probably not a fit
Patients who require urgent invasive intervention or have conditions where CTCA cannot accurately guide management may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter randomized trial compares CTCA-guided care to standard invasive coronary angiography in 1,000 patients with prior CABG who present with angina or myocardial infarction. In the CTCA arm, findings may support medical management and defer angiography. The study will track major adverse cardiovascular events, quality of life, and healthcare resource use to determine if CTCA improves outcomes and procedural safety. Participants undergo coronary imaging and follow-up assessments, with outcomes including death, MI, stroke, and hospitalizations. The trial builds on observational data suggesting potential benefits of CTCA in this population and aims to provide definitive evidence.
Why it matters
Potential benefit: If successful, CTCA-guided planning could reduce unnecessary invasive procedures, lower radiation exposure and contrast use, and improve overall outcomes for patients after CABG.
How similar studies have gone: Previous observational data suggested potential improvements with CTCA before angiography, but robust randomized evidence is still needed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged ≥18 * Previous coronary artery bypass grafting (CABG) * An indication for coronary angiography * Angina * Ischaemia on perfusion imaging * Acute coronary syndrome * Patients are able and willing to give their written informed consent Exclusion Criteria: * Subjects presenting with ST segment myocardial infarction within window for primary PCI * Patients considered unsuitable to participate by the research team (e.g. due to medical reasons, laboratory abnormalities, or subject's unwillingness to comply with all study related procedures) * Life expectancy less than 1 year
Where it's running
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St Bartholomew's Hospital
London, United Kingdom Recruiting
Study contacts
- Principal investigator: Daniel Jones, MRCP, PhD — Queen Mary University of London
- Study coordinator: Mervyn Andiapen
- Email: mervyn.andiapen@nhs.net
- Phone: 0203 765 8707
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.