Condition

Colorectal Neoplasms clinical trials and research

• 69Clinical trials
• 3New in 30 days
• 42Countries

Newest Colorectal Neoplasms clinical trials

All recruiting trials (69)

• Biomarkers in Colorectal Cancer: A Longitudinal Study Using Biobanks and Blood Samples

  This study tests whether clinical and molecular biomarkers from tumor tissue and blood can predict treatment response, recurrence, and survival in adults with colorectal cancer undergoing surgery.

  Recruiting at 2 sites Vorarlberg Institute for Vascular Investigation and Treatment · Bregenz, Vorarlberg and 3 other locations · NCT07913802

• Prehabilitation with Resistance, Aerobic, or Both Before Colorectal Surgery

  Four pre-surgery exercise options (resistance, aerobic, both, or none) will be tested to see which best reduces complications after colorectal cancer surgery.

  Recruiting Semmelweis University · Budapest · NCT07896174

• ctDNA blood test to spot buried cancer after surgery or treatment in colorectal cancer

  A blood test that looks for specific KRAS mutations in circulating tumor DNA to see if colorectal cancer has left residual disease or is likely to relapse.

  Recruiting Masaryk Memorial Cancer Institute · Brno, Czech Republic · NCT07895459

• Multimodal Survival Predictor for Colorectal Liver Metastases After Surgery

  Researchers are testing a tool that combines MRI-derived tumor features with clinical data to predict survival after surgery for colorectal liver metastases.

  Recruiting Anhui Provincial Hospital · Hefei, Anhui · NCT07830576

• Methylscape test in body fluids for multi-cancer detection in Colombia

  A simple blood, urine, or saliva test called Methylscape is being tested to see if it can detect multiple cancers and identify where the signal is coming from, using people with cancer and healthy volunteers in Colombia.

  Recruiting Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo · Bogotá, Bogota D.C. · NCT07741435

• AI-powered stool image analysis to see if it matches FIT results in colorectal cancer screening

  We’re testing whether AI-derived features from stool images can align with FIT results in adults being screened or evaluated for colorectal neoplasia.

  Recruiting Servicio de Salud Metropolitano Sur Oriente · Santiago, Santiago Metropolitan · NCT07740122

• A web-based tool to help predict submucosal invasive cancer in large non-pedunculated colorectal polyps

  A web-based decision aid is being tested to see if it can help endoscopists predict cancer invasion in large non-pedunculated colorectal polyps during live colonoscopies.

  Recruiting University Hospital, Ghent · Ghent · NCT07705880

• First-in-human test of BLU-924 for KRAS-mutant advanced cancers

  This trial tests BLU-924 in adults with KRAS-mutant advanced solid tumors, including PDAC, NSCLC, and CRC, to see if it is safe and may help control cancer.

  Recruiting at 3 sites Phase 1/2 Blueprint Medicines Corporation · Sarasota, Florida and 15 other locations · NCT07629960

• Text reminders to boost colorectal cancer screening participation

  A large group of people aged 50–69 in Vallès Occidental will be randomised to receive a reminder text message five weeks after an initial invitation, to see if it increases uptake of the FIT screening compared with the standard postal letter.

  Recruiting Corporacion Parc Tauli · Sabadell, Catalonia · NCT07628998

• No abdominal incision in minimally invasive colorectal surgery: a multicenter registry of natural orifice specimen extraction

  This registry follows adults having minimally invasive colorectal surgery to compare outcomes when the specimen is removed through a natural opening versus through an abdominal incision.

  Recruiting Singapore General Hospital · Singapore · NCT07615036

• Dabrafenib and trametinib for rare cancers with BRAF V600 mutations

  This arm tests whether dabrafenib and trametinib can help adults, children, and teens with cancers that have a BRAF V600 mutation.

  Recruiting at 15 sites Phase 2/3 Cancer Research UK · Belfast and 26 other locations · NCT07440290

• ULTRA-SAFE: Personalize colorectal cancer surveillance using annual FIT with optional earlier colonoscopy

  This trial tests whether annual fecal immunochemical testing (FIT) with earlier colonoscopy on positive results is better than a fixed colonoscopy at three years for people at very high risk after removing multiple advanced adenomas.

  Recruiting at 4 sites National Taiwan University Hospital · Taipei, Taipei and 3 other locations · NCT07378930

• Computer-aided detection during screening colonoscopy to lower advanced adenoma risk at 3 years

  This trial tests whether using computer-aided detection (CADe) during screening colonoscopy can lower the chance of developing advanced polyps or interval colorectal cancer over three years in adults having screening after a positive FIT or with personal or family risk factors.

  Recruiting University Hospital, Bordeaux · Bayonne and 14 other locations · NCT07299071

• Health behavior change program for people at high risk of colorectal cancer

  This project will test a 12-week support program to help adults at high risk for colorectal cancer improve diet, exercise, and other lifestyle habits.

  Recruiting China Medical University, China · Shenyang, Liaoning · NCT07262840

• Cetuximab beta plus fruquintinib, with or without immunotherapy, for first-line treatment of RAS/BRAF wild‑type unresectable metastatic colorectal cancer

  This trial tests whether combining cetuximab beta and fruquintinib, with or without immune checkpoint inhibitors, can control cancer as a chemotherapy‑free first‑line option for patients with RAS/BRAF wild‑type unresectable metastatic colorectal cancer.

  Recruiting Phase 2 Zhejiang University · Hangzhou, Zhejiang · NCT07257653

• Dexmedetomidine plus desflurane anesthesia for elective laparoscopic colectomy

  This trial will test whether adding dexmedetomidine to desflurane anesthesia helps adults having elective laparoscopic colectomy use less desflurane, maintain steadier blood pressure and heart rate during surgery, and recover faster afterward.

  Recruiting Tam Anh Research Institute · Ho Chi Minh City, Ho Chi Minh · NCT07239479

• PF-08634404 plus chemotherapy for adults with metastatic colorectal cancer

  This trial will test whether adding a new drug called PF-08634404 to standard chemotherapy helps adults whose colorectal cancer has spread.

  Recruiting at 343 sites Phase 3 Pfizer · Chandler, Arizona and 371 other locations · NCT07222800

• LY4337713 for people with FAP-positive ovarian, breast, pancreatic, colorectal, or esophageal cancers

  This trial tests LY4337713, a FAP-targeted lutetium-177 therapy, in people with advanced cancers that show high levels of fibroblast activation protein (FAP).

  Recruiting at 17 sites Phase 1 Eli Lilly and Company · Newport Beach, California and 29 other locations · NCT07213791

• DPYD-guided fluoropyrimidine dose adjustment for patients with one DPYD gene variant

  This trial will test whether giving lower doses of fluoropyrimidine chemotherapy based on a patient's DPYD gene result reduces severe (Grade 3–4) side effects in people with colorectal, breast, or head and neck cancers who carry one DPYD variant.

  Recruiting at 12 sites Phase 4 Rutgers, The State University of New Jersey · Belleville, New Jersey and 11 other locations · NCT07158164

• LY4257496 for GRPR-positive advanced breast, colorectal, prostate, and endometrial cancer (OMNIRAY)

  This Phase 1 test tries LY4257496, with GRPR imaging using LY4257529 and sometimes standard treatments, to see if it is safe and helps people with GRPR-positive advanced breast, colorectal, prostate, or endometrial cancer.

  Recruiting at 15 sites Phase 1 Eli Lilly and Company · Duarte, California and 32 other locations · NCT07114601

• High-sensitivity blood test to detect and monitor multiple cancers

  This study will test a high-sensitivity blood test that looks for tumor DNA to detect and follow several common cancers in adults with those cancers or people having routine health screenings.

  Recruiting Yonsei University · Seoul · NCT07035587

• Blood test for early detection of colorectal cancer

  This study is testing a new blood test to see if it can find colorectal cancer early in people with Lynch Syndrome, who are at higher risk for this disease.

  Recruiting Erasmus Medical Center · Leiden, South Holland and 1 other locations · NCT06989814

• Comparing at-home fecal blood testing (FIT) versus colonoscopy after polyp removal

  This will test whether at-home fecal immunochemical tests (FIT) can safely replace routine follow-up colonoscopy for people who have had colorectal polyps removed.

  Recruiting Sorlandet Hospital HF · Arendal, Agder · NCT06983639

• PRIORITY-CONNECT 2: virtual prehabilitation and recovery support for people having colorectal cancer surgery

  This trial tests whether a personalised virtual prehabilitation and recovery program with exercise, nutrition, and mental health support can lower 30-day complications for people having colorectal cancer surgery compared with usual care.

  Recruiting at 13 sites Surgical Outcomes Research Centre (SOuRCe) · Coffs Harbour, New South Wales and 30 other locations · NCT06976710

• Comparing two methods for detecting colorectal polyps during colonoscopy

  This study is testing which method, Linked-color imaging or indigo carmine chromoendoscopy, is better at finding colorectal polyps during colonoscopy for people aged 45 to 85 who have had polyps before or have related symptoms.

  Recruiting Shandong University · Jinan, Shandong · NCT06961149

• Combining hydroxychloroquine with chemotherapy for advanced colorectal cancer

  This study is testing if adding hydroxychloroquine to standard chemotherapy can help people with advanced colorectal cancer live longer and feel better.

  Recruiting Phase 2 Pavlov First Saint Petersburg State Medical University · Saint Petersburg, Sankt-Peterburg · NCT06949982

• Treatment for liver metastases from colorectal cancer using a combination of therapies

  This study is testing if a new combination of treatments for liver cancer from colorectal cancer can help patients live longer compared to the standard treatment they would usually receive.

  Recruiting Phase 3 The Netherlands Cancer Institute · Amsterdam · NCT06857773

• Testing DM002 in patients with advanced solid tumors

  This study is testing a new drug called DM002 to see if it is safe and effective for people with advanced solid tumors.

  Recruiting at 7 sites Phase 1/2 Doma Biopharmaceutical（Suzhou）Co., Ltd. · San Francisco, California and 6 other locations · NCT06751329

• Comparing Amivantamab with FOLFIRI to Cetuximab/Bevacizumab with FOLFIRI for Colorectal Cancer

  This study is testing if a new treatment combining amivantamab with FOLFIRI can help people with certain types of colorectal cancer live longer and feel better compared to the standard treatment with cetuximab or bevacizumab plus FOLFIRI.

  Recruiting at 235 sites Phase 3 Janssen Research & Development, LLC · Chandler, Arizona and 250 other locations · NCT06750094

• Testing JNJ-89402638 for advanced colorectal cancer

  This study is testing a new drug called JNJ-89402638 to see if it is safe and what the right dose is for people with advanced colorectal cancer that hasn't responded to other treatments.

  Recruiting at 12 sites Phase 1 Janssen Research & Development, LLC · Tucson, Arizona and 11 other locations · NCT06663319

• Comparing two treatments for advanced left-sided colorectal cancer

  This study is testing whether a new drug called amivantamab combined with standard chemotherapy works better than cetuximab with the same chemotherapy for people with advanced left-sided colorectal cancer that can't be surgically removed.

  Recruiting at 233 sites Phase 3 Janssen Research & Development, LLC · Gilbert, Arizona and 238 other locations · NCT06662786

• Evaluating LY4170156 for advanced solid tumors

  This study is testing a new drug called LY4170156 to see if it is safe and effective for people with advanced solid tumors like ovarian and lung cancers.

  Recruiting at 24 sites Phase 1 Eli Lilly and Company · Scottsdale, Arizona and 24 other locations · NCT06400472

• Testing UCB4594 for advanced cancer treatment

  This study is testing a new drug called UCB4594 to see if it can help treat advanced cancer by targeting a specific protein on cancer cells.

  Recruiting at 3 sites Phase 1/2 Cancer Research UK · London and 3 other locations · NCT06380816

• Nocardia rubra cell wall skeleton added to prior second- or third-line therapy for potentially hazardous stable colorectal cancer

  This test tries adding Nocardia rubra cell wall skeleton to prior second- or third-line treatments for adults with advanced colorectal cancer who have a potentially hazardous stable disease to see if it better controls their cancer.

  Recruiting Phase 2 The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT06356714

• Blood test for early detection of colorectal cancer and adenomas

  This study is testing a new blood test to see if it can help find early signs of colorectal cancer and adenomas in people who are already scheduled for a colonoscopy.

  Recruiting at 6 sites City of Hope Medical Center · Monrovia, California and 5 other locations · NCT06342440

• Detecting early onset colorectal cancer using a blood test

  This study is testing a new blood test that looks for specific markers to help find early signs of colorectal cancer in young adults.

  Recruiting at 13 sites City of Hope Medical Center · Duarte, California and 12 other locations · NCT06342401

• Evaluating anti-EGFR therapy effectiveness in specific colorectal cancer patients

  This study is testing if a personalized treatment approach using anti-EGFR therapy can help people with left-sided RAS-wild type metastatic colorectal cancer do better than standard chemotherapy.

  Recruiting at 3 sites Phase 3 City Clinical Oncology Hospital No 1 · Moscow and 2 other locations · NCT06226857

• Testing a new drug for adults with advanced solid tumors

  This study is testing a new drug for adults with advanced solid tumors that haven't responded to other treatments to see if it can help them.

  Recruiting at 43 sites Phase 1 Seagen Inc. · Phoenix, Arizona and 47 other locations · NCT06131840

• Assessing minimal residual disease in colorectal cancer using blood tests

  This study is testing if a blood test for cancer DNA can help doctors find out which colorectal cancer patients are at risk of their cancer coming back after surgery and if they need extra treatment.

  Recruiting at 9 sites University of Aarhus · Copenhagen, Capital Region of Denmark and 9 other locations · NCT06076811

• Using a microwave device to improve colonoscopy for detecting polyps

  This study is testing a new microwave device during colonoscopies to see if it can help doctors find more polyps that might be missed with regular methods.

  Recruiting MiWEndo Solutions S.L. · Barcelona · NCT05988645

• Evaluating HTL0039732 for Advanced Solid Tumours

  This study is testing a new drug called HTL0039732, alone and with another treatment, to see if it can help people with advanced solid tumors by boosting their immune response against cancer.

  Recruiting at 6 sites Phase 1/2 Cancer Research UK · Cambridge and 5 other locations · NCT05944237

• Platform program for evaluating treatments in metastatic HER2-positive breast cancer

  This study is testing different new treatments for people with advanced HER2-positive breast cancer to see which ones work best before moving them to larger trials.

  Recruiting at 5 sites Phase 1/2 QuantumLeap Healthcare Collaborative · Birmingham, Alabama and 9 other locations · NCT05868226

• Combination of trastuzumab and pertuzumab for treating cancers with HER2 mutations

  This study is testing if a combination of two cancer drugs, trastuzumab and pertuzumab, can help adults and young people with cancers that have HER2 mutations or amplifications.

  Recruiting at 24 sites Phase 2/3 Cancer Research UK · Belfast and 26 other locations · NCT05786716

• Using atezolizumab to treat cancers with high mutation rates or specific genetic deficiencies

  This study is testing if atezolizumab can help treat adults and kids with certain types of cancers that have a lot of genetic changes or specific genetic issues.

  Recruiting at 23 sites Phase 2/3 Cancer Research UK · Belfast and 26 other locations · NCT05770102

• Combination of vemurafenib and cobimetinib for treating BRAF positive cancers

  This study is testing if the combination of vemurafenib and cobimetinib can help adults with different types of cancers that have a specific BRAF mutation.

  Recruiting at 16 sites Phase 2/3 Cancer Research UK · Belfast and 15 other locations · NCT05768178

• Exploring biomarkers to improve treatment for metastatic colorectal cancer

  This study is testing if certain biological markers can help doctors tailor treatment for people with advanced colorectal cancer to improve their response to medication and reduce side effects.

  Recruiting Maastricht University Medical Center · Maastricht, Limburg · NCT05655780

• Comparing colonoscopy and stool testing for older adults with colon polyps

  This study is testing whether a simple stool test can be just as effective as colonoscopy for monitoring older adults with a history of colon polyps.

  Recruiting at 22 sites Dartmouth-Hitchcock Medical Center · Birmingham, Alabama and 23 other locations · NCT05612347

• New oral synbiotic formula to reduce colorectal adenoma recurrence

  This study is testing a new oral formula made of probiotics and prebiotics to see if it can help prevent the return of certain growths in the colon after they've been removed.

  Recruiting Chinese University of Hong Kong · Hohhot, Inner Mongolia and 1 other locations · NCT05592886

• Personalized treatment approach for colorectal cancer

  This study is testing a new way to find the best cancer treatments for people with colorectal cancer by using their own tumor samples to see how different drugs work together.

  Recruiting University Hospital, Akershus · Lørenskog, Akershus · NCT05401318

• Using a fecal test to reduce unnecessary colonoscopies after polyp removal

  This study is testing whether a simple stool test can help people with a history of polyps or family history of colorectal cancer avoid unnecessary colonoscopies.

  Recruiting University of Calgary · Calgary, Alberta · NCT05396560

• Combining PDS01ADC with targeted liver chemotherapy for certain cancers

  This study is testing if a new cancer treatment that combines an immune booster with targeted liver chemotherapy can help people with certain advanced cancers feel better and live longer.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05286814

• Combination treatment for HER2 positive metastatic colorectal cancer

  This study is testing a new combination of tucatinib, trastuzumab, and mFOLFOX6 to see if it helps people with HER2 positive metastatic colorectal cancer more than the usual treatments.

  Recruiting at 298 sites Phase 3 Seagen Inc. · Glendale, Arizona and 365 other locations · NCT05253651

• Comparing Fleet Enema and Oral Prep for Bowel Cleansing Before Surgery

  This study is testing whether using Fleet enemas or a drink called Pico Salax is better for cleaning out the rectum before surgery to remove rectal lesions.

  Recruiting Phase 4 Nova Scotia Health Authority · Halifax, Nova Scotia · NCT05148494

• Impact of cancer treatments on reproductive and sexual health in young colorectal cancer patients

  This study looks at how chemotherapy and radiation therapy affect the reproductive and sexual health of young people with early onset colorectal cancer.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT04812912

• New drug metarrestin for treating metastatic solid tumors

  This study is testing a new drug called metarrestin to see if it can safely shrink tumors in adults and teens with advanced solid tumors that haven't responded to other treatments.

  Recruiting at 2 sites Phase 1 National Institutes of Health Clinical Center (CC) · Fairway, Kansas and 1 other locations · NCT04222413

• Evaluating tumor characteristics and treatment response in colorectal cancer patients

  This study is testing how different tumor features and treatments affect adults with colorectal cancer by collecting samples from their bodies to learn more about the disease.

  Recruiting Sahlgrenska University Hospital · Gothenburg · NCT04130971

• Preventing colorectal cancer metastasis after surgery

  This study is testing whether a combination of two medications, propranolol and etodolac, can help prevent the spread of colorectal cancer after surgery.

  Recruiting Phase 2 Assaf-Harofeh Medical Center · Afula and 5 other locations · NCT03919461

• Using SGM-101 to improve tumor visualization during colorectal cancer surgery

  This study is testing a new imaging agent called SGM-101 to see if it can help doctors see colorectal tumors better during surgery, which might lead to better outcomes for patients.

  Recruiting at 10 sites Phase 3 Surgimab · Duarte, California and 10 other locations · NCT03659448

• Investigating factors influencing cancer risk in people with Lynch syndrome

  This study is trying to find out how lifestyle, diet, and genetics affect cancer risk in people with Lynch syndrome.

  Recruiting Wageningen University · Wageningen · NCT03303833

• Second-line FOLFIRI +/- Bevacizumab vs Irinotecan +/- Bevacizumab in Metastatic Colorectal Cancer

  This trial tests whether a second-line FOLFIRI-based regimen with or without Bevacizumab is as good as Irinotecan-based therapy with or without Bevacizumab for patients with metastatic colorectal cancer.

  Recruiting Phase 3 Sun Yat-sen University · Guangzhou, Guangdong · NCT03303495

• Treatment for liver metastases in colorectal cancer

  This study is testing a new combination of chemotherapy treatments for patients with colorectal cancer that has spread to the liver, to see if it can help them live longer and feel better when surgery isn't an option.

  Recruiting at 35 sites Phase 3 Federation Francophone de Cancerologie Digestive · Brussels and 48 other locations · NCT02885753

• Database of patients with colorectal cancer at Institut Paoli Calmettes

  This study is creating a database of people with colorectal cancer to help researchers understand the disease better and improve care for future patients.

  Recruiting Institut Paoli-Calmettes · Marseille, Bouches du Rhone · NCT02869503

• Registry for patients undergoing colorectal surgery for cancer

  This study is inviting adults having surgery for colorectal cancer to help gather important health information and samples to better understand the disease and improve future treatments.

  Recruiting Hospital Italiano de Buenos Aires · CABA, Buenos Aires · NCT02781337

• Testing personalized cancer treatments using patient-derived tumors in mice

  This study is trying to see if using personalized tumor samples from patients with certain types of cancer in mice can help find the best treatments for those patients.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT02732860

• Screening for liver metastases in high-risk colorectal cancer patients using MRI

  This study is testing if a special type of MRI can find liver cancer spread earlier in patients with high-risk colorectal cancer compared to regular CT scans.

  Recruiting at 12 sites Imperial College London · Macclesfield, Cheshire and 12 other locations · NCT02246634

• Using MRI to Improve Treatment for Sigmoid Colon Cancer

  This study is testing if using MRI scans can help doctors plan better treatments for patients with sigmoid colon cancer compared to regular CT scans.

  Recruiting at 15 sites Imperial College London · Huntingdon, Cambridgeshire and 15 other locations · NCT02222844

• Collecting tumor tissue samples from patients undergoing surgery or biopsy for cancer

  This study is collecting tissue samples from cancer patients having surgery or biopsies to see if they can find new ways to treat different types of cancer.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01915225

• Creating a bank of tumor tissue samples for research

  This study is creating a collection of tumor tissue samples from cancer patients and healthy individuals to help researchers find better ways to diagnose and treat cancer.

  Recruiting Medical University of Vienna · Vienna and 2 other locations · NCT01789229

• Creating a tumor bank for blood samples from cancer patients and healthy controls

  This study is collecting blood samples from cancer patients and healthy people to help researchers find better ways to diagnose and treat cancer.

  Recruiting Medical University of Vienna · Innsbruck and 5 other locations · NCT01763125

Related topics

Quick answers

How many Colorectal Neoplasms clinical trials are recruiting right now?

69, as of November 12, 2026. 3 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 42 countries. The most sites are in United States (21 trials), China (15 trials), Spain (13 trials), United Kingdom (12 trials), Netherlands (10 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 9, Phase 1: 6, Phase 2: 5, Phase 1/2: 5. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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