Dexmedetomidine plus desflurane anesthesia for elective laparoscopic colectomy
Official title: Efficacy and Safety of Dexmedetomidine Combined With Desflurane in Laparoscopic Colectomy: A Randomized Double-Blind Controlled Clinical Trial (DEXDES Trial)
Run by Tam Anh Research Institute · NCT07239479 · Data updated 2026-11-12
This trial will test whether adding dexmedetomidine to desflurane anesthesia helps adults having elective laparoscopic colectomy use less desflurane, maintain steadier blood pressure and heart rate during surgery, and recover faster afterward.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Tam Anh Research Institute Academic / other |
| Locations | 1 site (Ho Chi Minh City, Ho Chi Minh) |
| Status | Recruiting |
| Started | December 1, 2025 |
| Main results expected | December 31, 2026 |
| Study ends | January 30, 2027 |
| Registry record updated | December 30, 2025 |
| Trial ID | NCT07239479 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–65 with ASA physical status I–II scheduled for elective laparoscopic colectomy who can provide informed consent are the intended participants.
✕Probably not a fit
Patients with severe cardiac, hepatic, or renal disease, COPD or asthma, atrioventricular block or sick sinus syndrome, chronic opioid or psychotropic use, or significant intraoperative bleeding/hemodynamic instability are excluded and unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a randomized, double-blind controlled trial enrolling 40 adult patients undergoing elective laparoscopic colectomy at Tam Anh TP. Ho Chi Minh General Hospital. Participants are randomized to receive either dexmedetomidine with desflurane or desflurane with saline placebo during general anesthesia. The primary outcome is average desflurane consumption per hour, with secondary outcomes including intraoperative hemodynamic parameters, fentanyl consumption, quality of emergence, and incidence of postoperative nausea and vomiting within an ERAS framework. Safety and anesthetic-sparing effects will be compared between groups.
Why it matters
Potential benefit: If successful, the combination could reduce desflurane use, lower opioid requirements, stabilize intraoperative hemodynamics, and speed postoperative recovery and discharge.
How similar studies have gone: Previous studies combining dexmedetomidine with volatile anesthetics have shown anesthetic-sparing effects and improved emergence profiles, though specific data pairing dexmedetomidine with desflurane in laparoscopic colectomy are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-65 years * ASA Physical Status I-II * Elective laparoscopic colectomy * Written informed consent provided Exclusion Criteria: * Severe cardiac, hepatic, or renal disease * COPD or bronchial asthma * Chronic opioid or psychotropic medication use * Atrioventricular block (grade II-III), sick sinus syndrome * Significant intraoperative bleeding or hemodynamic instability
Where it's running
-
Tam Anh TP. Ho Chi Minh General Hospital
Ho Chi Minh City, Ho Chi Minh, Vietnam Recruiting
Study contacts
- Study coordinator: Phan Quoc Thai, MD
- Email: thaipq@tahospital.vn
- Phone: +84 964 152 360
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Biomarkers in Colorectal Cancer: A Longitudinal Study Using Biobanks and Blood Samples
This study tests whether clinical and molecular biomarkers from tumor tissue and blood can predict treatment response, recurrence, and survival in adults with colorectal cancer undergoing surgery.
-
Prehabilitation with Resistance, Aerobic, or Both Before Colorectal Surgery
Four pre-surgery exercise options (resistance, aerobic, both, or none) will be tested to see which best reduces complications after colorectal cancer surgery.
-
ctDNA blood test to spot buried cancer after surgery or treatment in colorectal cancer
A blood test that looks for specific KRAS mutations in circulating tumor DNA to see if colorectal cancer has left residual disease or is likely to relapse.
-
Multimodal Survival Predictor for Colorectal Liver Metastases After Surgery
Researchers are testing a tool that combines MRI-derived tumor features with clinical data to predict survival after surgery for colorectal liver metastases.
-
Methylscape test in body fluids for multi-cancer detection in Colombia
A simple blood, urine, or saliva test called Methylscape is being tested to see if it can detect multiple cancers and identify where the signal is coming from, using people with cancer and healthy volunteers in Colombia.
-
AI-powered stool image analysis to see if it matches FIT results in colorectal cancer screening
We’re testing whether AI-derived features from stool images can align with FIT results in adults being screened or evaluated for colorectal neoplasia.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.