Condition

Esophageal Neoplasms clinical trials and research

• 23Clinical trials
• 25Countries

Newest Esophageal Neoplasms clinical trials

All recruiting trials (23)

• Proximal versus total gastrectomy for locally advanced Siewert type II–III gastroesophageal junction cancer

  This will see if keeping part of the stomach (proximal gastrectomy) or removing the whole stomach (total gastrectomy) leads to better 3-year disease-free survival for adults with locally advanced Siewert type II–III gastroesophageal junction cancer.

  Recruiting Bakirkoy Dr. Sadi Konuk Research and Training Hospital · Istanbul, Istanbul · NCT07482566

• Omega-3 supplements with PD-1 therapy for advanced esophageal cancer

  This trial will test whether taking omega-3 fish oil (EPA+DHA) together with PD-1 immunotherapy helps adults with recurrent or metastatic esophageal cancer maintain muscle and have better clinical and patient-reported outcomes than a placebo.

  Recruiting Fudan University · Shanghai, Shanghai Municipality · NCT07272382

• LY4337713 for people with FAP-positive ovarian, breast, pancreatic, colorectal, or esophageal cancers

  This trial tests LY4337713, a FAP-targeted lutetium-177 therapy, in people with advanced cancers that show high levels of fibroblast activation protein (FAP).

  Recruiting at 17 sites Phase 1 Eli Lilly and Company · Newport Beach, California and 29 other locations · NCT07213791

• LY4257496 for GRPR-positive advanced breast, colorectal, prostate, and endometrial cancer (OMNIRAY)

  This Phase 1 test tries LY4257496, with GRPR imaging using LY4257529 and sometimes standard treatments, to see if it is safe and helps people with GRPR-positive advanced breast, colorectal, prostate, or endometrial cancer.

  Recruiting at 15 sites Phase 1 Eli Lilly and Company · Duarte, California and 32 other locations · NCT07114601

• High-sensitivity blood test to detect and monitor multiple cancers

  This study will test a high-sensitivity blood test that looks for tumor DNA to detect and follow several common cancers in adults with those cancers or people having routine health screenings.

  Recruiting Yonsei University · Seoul · NCT07035587

• Combining Fruquintinib and Tislelizumab with Radiotherapy for Esophageal Cancer

  This study is testing if combining two new cancer treatments, Fruquintinib and Tislelizumab, with radiation can help people with advanced esophageal cancer feel better and improve their outcomes.

  Recruiting Phase 2 Hebei Medical University Fourth Hospital · Shijiazhuang, Hebei · NCT06646588

• Combination treatment for advanced esophageal cancer

  This study is testing a new combination of treatments for patients with advanced esophageal cancer to see if it is safe and effective for those who haven't had treatment before.

  Recruiting at 46 sites Phase 1/2 Merck Sharp & Dohme LLC · Tucson, Arizona and 49 other locations · NCT06469944

• Combination therapies for advanced gastroesophageal cancer

  This study is testing two different treatment combinations for people with advanced stomach cancer to see which one works better after their first treatment didn't help.

  Recruiting at 44 sites Phase 1/2 Merck Sharp & Dohme LLC · Tucson, Arizona and 45 other locations · NCT06445972

• Testing UCB4594 for advanced cancer treatment

  This study is testing a new drug called UCB4594 to see if it can help treat advanced cancer by targeting a specific protein on cancer cells.

  Recruiting at 3 sites Phase 1/2 Cancer Research UK · London and 3 other locations · NCT06380816

• Combining PD-1 inhibitors with chemotherapy and radiotherapy for metastatic esophageal cancer

  This study is testing if adding PD-1 inhibitors to chemotherapy and radiotherapy can help people with advanced esophageal cancer live longer and feel better.

  Recruiting Phase 3 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT06086457

• Comparing two solutions for endoscopic removal of early esophageal cancer

  This study is testing two different solutions to see which one works better for safely removing early esophageal cancer in patients.

  Recruiting Instituto do Cancer do Estado de São Paulo · São Paulo, São Paulo · NCT06077981

• Comparing two types of esophageal stents for treating swallowing difficulties in cancer patients

  This study is testing whether fully covered or partially covered esophageal stents can help cancer patients with swallowing difficulties feel better.

  Recruiting Instituto do Cancer do Estado de São Paulo · São Paulo, São Paulo · NCT06070376

• Evaluating HTL0039732 for Advanced Solid Tumours

  This study is testing a new drug called HTL0039732, alone and with another treatment, to see if it can help people with advanced solid tumors by boosting their immune response against cancer.

  Recruiting at 6 sites Phase 1/2 Cancer Research UK · Cambridge and 5 other locations · NCT05944237

• Bright-light exposure and exercise program for cancer patients

  This study is testing if a six-week program that combines bright-light exposure with exercise can help people with lung and esophageal cancer feel better and improve their quality of life.

  Recruiting at 2 sites Taipei Veterans General Hospital, Taiwan · Taipei City, Taipei and 1 other locations · NCT05875870

• Long-term outcomes of endoscopic procedures for upper gastrointestinal cancers

  This study looks at how well certain endoscopic procedures work for treating larger upper gastrointestinal cancers and what the long-term results are for patients.

  Recruiting Western Sydney Local Health District · Sydney, New South Wales · NCT05804331

• Nutritional management for patients with esophageal cancer

  This study tests if a personalized nutrition plan helps people with esophageal cancer feel better and manage their weight compared to standard nutrition advice.

  Recruiting The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT05800054

• Rehabilitation and recovery program for esophageal and gastric cancer patients

  This study is testing a personalized rehabilitation program for people with esophageal and gastric cancer to see if it can improve their quality of life and help manage their symptoms.

  Recruiting Region Skane · Lund, Lund · NCT05698992

• Searching for RNA biomarkers in Barrett's esophagus and esophageal adenocarcinoma

  This study is trying to find new RNA markers in blood samples that can help diagnose Barrett's esophagus and esophageal cancer in patients.

  Recruiting University Hospital, Ghent · Ghent, Oost-Vlaanderen · NCT05688176

• Combining camrelizumab with chemoradiotherapy for advanced esophageal cancer

  This study is testing if adding a new immunotherapy drug called camrelizumab to standard chemotherapy and radiation can help people with advanced esophageal cancer feel better and improve their treatment results.

  Recruiting Phase 2 Fujian Cancer Hospital · Fuzhou · NCT05624099

• Combination of Anlotinib and TQB2450 for Esophageal Cancer Treatment

  This study is testing if combining two medications, Anlotinib and TQB2450, can help people with esophageal cancer stay cancer-free after surgery.

  Recruiting Phase 2 Jiangxi Provincial Cancer Hospital · Nanchang, Jiangxi · NCT05252078

• Endoscopic removal of cancerous and precancerous lesions in the digestive tract

  This project looks back at adults who had endoscopic removal of upper or lower digestive tract tumors to see which resection techniques worked best and were safest.

  Recruiting Azienda USL Reggio Emilia - IRCCS · Reggio Emilia, RE · NCT04780256

• Evaluating lymph node metastases in esophageal cancer after surgery

  This study is trying to understand how lymph node cancer spreads in people with esophageal cancer after surgery to see if it can help predict their recovery and survival.

  Recruiting at 19 sites Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Houston, Texas and 18 other locations · NCT03222895

• Survey for patients with esophageal cancer and upper digestive diseases

  This study is trying to gather information from patients with esophageal cancer and other upper digestive issues to see how they are doing after treatment and improve future care.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT02530983

Related topics

Quick answers

How many Esophageal Neoplasms clinical trials are recruiting right now?

23, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 25 countries. The most sites are in China (11 trials), United States (6 trials), Brazil (5 trials), Germany (5 trials), Italy (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 4, Phase 2: 3, Phase 1: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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