Comparing two methods for detecting colorectal polyps during colonoscopy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effectiveness of Linked-color imaging (LCI) versus indigo carmine chromoendoscopy in detecting colorectal adenomas during colonoscopy. Participants aged 45 to 85 with a history of colorectal adenoma or related gastrointestinal symptoms will be randomly assigned to one of two groups: one receiving LCI and the other undergoing indigo carmine spraying. The study will analyze various data points, including lesion characteristics and colonoscopy duration, to determine which method yields a higher adenoma detection rate. Statistical analyses will be performed to assess the significance of the findings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age between 45 and 85 years
2. Patients with a history of colorectal adenoma
3. Patients whose first-degree relatives have a history of colorectal cancer or colorectal adenoma
4. Patients with gastrointestinal symptoms (abdominal pain, bloody stool, chronic diarrhea or constipation, Unexplained anemia or weight loss;
5. Patients with positive Fecal Immunochemical Test

Exclusion Criteria:

1. Patients with pregnancy, inflammatory bowel disease, familial adenomatosis polyposis, suspected CRC; intestinal obstruction, coagulopathy
2. Patients with aspirin, clopidogrel or other anticoagulants/ antiplatelet drugs intake within 7 days
3. Patents previous colorectal resection
4. Patients with failed cecal intubation
5. Patients with inadequate bowel preparation quality (BBPS≤5)
6. Patients who refuse to participate or to provide informed consent

Where it's running

• Qilu Hospital of Shandong University
  Jinan, Shandong, China Recruiting

Study contacts

• Study coordinator: Rui Ji MD PHD
• Email: qljirui@email.sdu.edu.cn
• Phone: +86-18560086103

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• A web-based tool to help predict submucosal invasive cancer in large non-pedunculated colorectal polyps

  A web-based decision aid is being tested to see if it can help endoscopists predict cancer invasion in large non-pedunculated colorectal polyps during live colonoscopies.

  Recruiting University Hospital, Ghent · Ghent · NCT07705880

• Biomarkers in Colorectal Cancer: A Longitudinal Study Using Biobanks and Blood Samples

  This study tests whether clinical and molecular biomarkers from tumor tissue and blood can predict treatment response, recurrence, and survival in adults with colorectal cancer undergoing surgery.

  Recruiting at 2 sites Vorarlberg Institute for Vascular Investigation and Treatment · Bregenz, Vorarlberg and 3 other locations · NCT07913802

• Prehabilitation with Resistance, Aerobic, or Both Before Colorectal Surgery

  Four pre-surgery exercise options (resistance, aerobic, both, or none) will be tested to see which best reduces complications after colorectal cancer surgery.

  Recruiting Semmelweis University · Budapest · NCT07896174

• ctDNA blood test to spot buried cancer after surgery or treatment in colorectal cancer

  A blood test that looks for specific KRAS mutations in circulating tumor DNA to see if colorectal cancer has left residual disease or is likely to relapse.

  Recruiting Masaryk Memorial Cancer Institute · Brno, Czech Republic · NCT07895459

• Multimodal Survival Predictor for Colorectal Liver Metastases After Surgery

  Researchers are testing a tool that combines MRI-derived tumor features with clinical data to predict survival after surgery for colorectal liver metastases.

  Recruiting Anhui Provincial Hospital · Hefei, Anhui · NCT07830576

• Methylscape test in body fluids for multi-cancer detection in Colombia

  A simple blood, urine, or saliva test called Methylscape is being tested to see if it can detect multiple cancers and identify where the signal is coming from, using people with cancer and healthy volunteers in Colombia.

  Recruiting Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo · Bogotá, Bogota D.C. · NCT07741435

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.