Detecting early onset colorectal cancer using a blood test

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on the rising incidence of early-onset colorectal cancer (EOCRC) among young adults, aiming to develop a non-invasive blood-based molecular assay utilizing microRNA for detection. The study will assess circulating cell-free and exosomal microRNAs to create a diagnostic model that enhances sensitivity and specificity for EOCRC. By employing machine learning and bioinformatics, the researchers intend to establish cost-effective and patient-friendly biomarkers that can improve screening participation among underserved populations. The ultimate goal is to facilitate timely detection of EOCRC, addressing a significant public health concern.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Stage I, II, III, IV colorectal cancer (TNM classification, 8th edition) diagnosed before the age of 50 (EOCRC cases)
* Received standard diagnostic and staging procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment
* Colonoscopy-proven cancer-free status at the time of study inclusion (Non-disease controls)

Exclusion Criteria:

* Hereditary colorectal cancer syndromes (identified through genetic testing)
* Inflammatory bowel diseases
* Lack of written informed consent

Where it's running

• City of Hope Medical Center
  Duarte, California, United States Recruiting
• IRCCS San Raffaele
  Milan, Italy Recruiting
• Kawasaki University
  Kawasaki, Japan Recruiting
• Mie University
  Mie, Japan Recruiting
• National Cancer Center Hospital
  Tokyo, Japan Recruiting
• Tokyo Medical and Dental University
  Tokyo, Japan Recruiting

Study contacts

• Principal investigator: Ajay Goel, PhD — City of Hope Medical Center
• Study coordinator: Ajay Goel, PhD
• Email: AJGOEL@COH.ORG
• Phone: 626-218-3452

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.