Using MRI to Improve Treatment for Sigmoid Colon Cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial evaluates whether MRI imaging can enhance the treatment planning for patients with suspected or confirmed sigmoid colon adenocarcinoma who are eligible for curative treatment. Participants are randomly assigned to either a control group receiving standard preoperative CT imaging or an intervention group that includes MRI imaging. The study aims to determine if MRI can identify high-risk tumors more effectively than CT, potentially altering treatment plans based on additional diagnostic information. Patients will be followed up at 1 and 3 years to assess outcomes and quality of life.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Have a suspected or proven sigmoid colon adenocarcinoma
2. Is eligible for curative treatment
3. Has no irresectable metastatic disease
4. MRI can be reviewed by an MDT prior to surgery
5. Has no decision regarding radical treatment
6. Have provided written informed consent to participate in the study
7. Be aged 16 years or over

Exclusion Criteria:

1. Have metastatic disease (including resectable liver metastases)
2. Have a synchronous second malignancy
3. Are contraindicated for MRI
4. Are contraindicated for or have allergy to Buscopan (e.g. glaucoma, small or large bowel obstruction, GFR\<30)
5. Have severe co-morbidities or previous medical history that prevent the application of eventual chemo/radiotherapy

Where it's running

• Hinchingbrooke Hospital
  Huntingdon, Cambridgeshire, United Kingdom Recruiting
• Leighton Hospital
  Crewe, Cheshire, United Kingdom Recruiting
• University Hospital of North Tees
  Stockton-on-Tees, County Durham, United Kingdom Recruiting
• Croydon University Hospital
  Thornton Heath, Croydon, United Kingdom Recruiting
• Chesterfield Royal
  Chesterfield, Derbyshire, United Kingdom Recruiting
• Queen Alexandra Hospital
  Portsmouth, Hampshire, United Kingdom Recruiting

Study contacts

• Principal investigator: Gina Brown — Imperial College London
• Study coordinator: Caroline Martin
• Email: c.martin1@imperial.ac.uk
• Phone: +44 (0) 7749 655 817

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.