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Using MRI to Improve Treatment for Sigmoid Colon Cancer

Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers

Not applicable Interventional Imperial College London · NCT02222844

This study is testing if using MRI scans can help doctors plan better treatments for patients with sigmoid colon cancer compared to regular CT scans.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment244 (estimated)
Ages16 Years and up
SexAll
SponsorImperial College London Academic / other
Locations16 sites (Huntingdon, Cambridgeshire and 15 other locations)
Trial IDNCT02222844 on ClinicalTrials.gov

What this trial studies

This trial evaluates whether MRI imaging can enhance the treatment planning for patients with suspected or confirmed sigmoid colon adenocarcinoma who are eligible for curative treatment. Participants are randomly assigned to either a control group receiving standard preoperative CT imaging or an intervention group that includes MRI imaging. The study aims to determine if MRI can identify high-risk tumors more effectively than CT, potentially altering treatment plans based on additional diagnostic information. Patients will be followed up at 1 and 3 years to assess outcomes and quality of life.

Who should consider this trial

Good fit: Ideal candidates are individuals aged 16 and over with suspected or proven sigmoid colon adenocarcinoma who are eligible for curative treatment.

Not a fit: Patients with metastatic disease, contraindications for MRI, or severe co-morbidities may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to more personalized and effective treatment plans for patients with sigmoid colon cancer.

How similar studies have performed: Other studies have shown that advanced imaging techniques like MRI can improve treatment outcomes in various cancers, suggesting a promising avenue for this approach.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Have a suspected or proven sigmoid colon adenocarcinoma
2. Is eligible for curative treatment
3. Has no irresectable metastatic disease
4. MRI can be reviewed by an MDT prior to surgery
5. Has no decision regarding radical treatment
6. Have provided written informed consent to participate in the study
7. Be aged 16 years or over

Exclusion Criteria:

1. Have metastatic disease (including resectable liver metastases)
2. Have a synchronous second malignancy
3. Are contraindicated for MRI
4. Are contraindicated for or have allergy to Buscopan (e.g. glaucoma, small or large bowel obstruction, GFR\<30)
5. Have severe co-morbidities or previous medical history that prevent the application of eventual chemo/radiotherapy

Where this trial is running

Huntingdon, Cambridgeshire and 15 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions CancerColorectal NeoplasmsColon, SigmoidMagnetic Resonance ImagingGeneral SurgeryPostoperative Complications
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.