Condition

Colorectal Adenocarcinoma clinical trials and research

• 25Clinical trials
• 25Countries

Newest Colorectal Adenocarcinoma clinical trials

All recruiting trials (25)

• BiP inhibitor BPR001-615 in colorectal adenocarcinoma

  This study tests whether the BiP inhibitor BPR001-615 can affect cancer cells from colorectal adenocarcinoma, in patients who will have surgical removal of their tumor at Nice University Hospital.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice · NCT07813884

• VVD-133214 with Pembrolizumab in advanced colorectal cancer

  This study tests whether adding VVD-133214 to pembrolizumab helps people with advanced colorectal cancer better than pembrolizumab alone.

  Recruiting at 9 sites Phase 2 Vividion Therapeutics, Inc. · Tucson, Arizona and 121 other locations · NCT07811193

• Paclitaxel given inside the abdomen with systemic therapy for GI cancers with peritoneal spread

  This phase II study tests a combination of intraperitoneal and systemic chemotherapy (paclitaxel) in adults with digestive tract cancers that have spread to the peritoneum.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT07795749

• Breath test to help detect gastrointestinal cancers early

  A breath test that looks for signals in exhaled air to see if someone with gut cancer symptoms might have oesophageal, stomach, pancreatic, liver, or colorectal cancer and need urgent testing.

  Recruiting Imperial College London · Maidstone, Kent and 5 other locations · NCT07714538

• TLR9-based immunotherapy for peritoneal cancer with ascites

  This trial tests ACM-CpG injections into the abdomen to see if it’s safe and can help people with peritoneal metastases or malignant ascites from colorectal or appendiceal cancer.

  Recruiting Phase 1 Brown University · Providence, Rhode Island · NCT07658196

• Combining botensilimab and balstilimab after standard treatment for colorectal cancer

  This phase 2 trial tests whether giving botensilimab and balstilimab after standard therapy can clear detectable ctDNA in adults with stage II/III colorectal cancer.

  Recruiting at 2 sites Phase 2 National Cancer Institute (NCI) · New Orleans, Louisiana and 1 other locations · NCT07551596

• First-line trastuzumab-deruxtecan with capecitabine and bevacizumab for HER2-positive metastatic colorectal cancer

  This trial tests whether giving trastuzumab-deruxtecan together with capecitabine and bevacizumab as first treatment helps people with HER2-positive metastatic or unresectable colorectal cancer shrink tumors and respond better.

  Recruiting at 28 sites Phase 2 Gruppo Oncologico del Nord-Ovest · Lyon and 27 other locations · NCT07407465

• Mass-based drug screening to guide personalized HIPEC for high-grade appendiceal and colorectal cancer with peritoneal spread.

  This tests whether a lab-based mass response test on tumor biopsies can pick the best chemotherapy to use during repeated HIPEC for people with unresectable peritoneal metastases from high-grade appendiceal or colorectal cancer.

  Recruiting Yale University · New Haven, Connecticut · NCT07291180

• Family genetics: who shares test results with relatives

  This study tests whether letting patients share genetic results with their relatives is as good as doctors sharing the results to help first-degree relatives get genetic testing for hereditary cancer risk.

  Recruiting at 362 sites Alliance for Clinical Trials in Oncology · Birmingham, Alabama and 364 other locations · NCT07143487

• Nectin-4 targeted alpha radiotherapy [225Ac]Ac-AKY-1189 for advanced solid tumors

  This trial will try a Nectin‑4–targeted radioactive drug called [225Ac]Ac‑AKY‑1189 in adults with locally advanced or metastatic solid tumors, including certain bladder, breast, lung, and cervical cancers.

  Recruiting at 14 sites Phase 1 Aktis Oncology, Inc. · Duarte, California and 13 other locations · NCT07020117

• Skin tests to check biotherapy allergies in cancer patients

  We are testing skin tests to see if cancer patients treated with biotherapies have allergies or hypersensitivity to those drugs.

  Recruiting University Hospital, Angers · Angers · NCT06971848

• Measuring MMP-14 protein in blood exosomes to help detect colorectal cancer

  This research tries to see if measuring MMP-14 in tiny blood particles called exosomes can help detect colorectal cancer in people with a positive FIT who are scheduled for colonoscopy.

  Recruiting CHU de Reims · Reims · NCT06955767

• AK112 plus chemotherapy versus bevacizumab plus chemotherapy for first-line metastatic colorectal cancer

  This tests whether adding AK112 to standard chemotherapy works better than bevacizumab plus chemotherapy as the first treatment for people with metastatic colorectal cancer.

  Recruiting at 2 sites Phase 3 Akeso · Guanzhou, Guangdong and 1 other locations · NCT06951503

• AK129 combination therapy for advanced solid tumors

  This study tests AK129 given with chemotherapy in adults with advanced non-small cell lung, head and neck, or colorectal cancers to find a safe dose and see if it helps control their disease.

  Recruiting Phase 1/2 Akeso · Shenyang, Liaoning · NCT06943820

• Treatment for adult patients with solid tumors that have a specific p53 mutation

  This study is testing a new treatment for adults with advanced solid tumors that have a specific p53 mutation to see if it is safe and effective.

  Recruiting at 21 sites Phase 1 Clasp Therapeutics, Inc. · Scottsdale, Arizona and 20 other locations · NCT06778863

• Evaluating a new CAR T-cell therapy for solid tumors expressing EGFR

  This study is testing a new CAR T-cell therapy to see if it can safely help adults with certain solid tumors, like colorectal and lung cancer, that have specific markers.

  Recruiting at 10 sites Phase 1/2 A2 Biotherapeutics Inc. · Gilbert, Arizona and 9 other locations · NCT06682793

• Blood test for early detection of colorectal cancer and adenomas

  This study is testing a new blood test to see if it can help find early signs of colorectal cancer and adenomas in people who are already scheduled for a colonoscopy.

  Recruiting at 6 sites City of Hope Medical Center · Monrovia, California and 5 other locations · NCT06342440

• Detecting early onset colorectal cancer using a blood test

  This study is testing a new blood test that looks for specific markers to help find early signs of colorectal cancer in young adults.

  Recruiting at 13 sites City of Hope Medical Center · Duarte, California and 12 other locations · NCT06342401

• Predicting recurrence in stage II/III colorectal cancer after chemotherapy

  This study is trying to create a test that can help predict if people with stage II/III colorectal cancer will have their cancer come back after chemotherapy.

  Recruiting at 4 sites City of Hope Medical Center · Monrovia, California and 3 other locations · NCT06314958

• Fluoxetine treatment to modify immune cells in colorectal cancer patients before surgery

  This study is testing if taking fluoxetine for 10 days can change the immune cells in colorectal cancer patients before their surgery to see if it helps slow down tumor growth.

  Recruiting Phase 1 Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT06225011

• Assessing minimal residual disease in colorectal cancer using blood tests

  This study is testing if a blood test for cancer DNA can help doctors find out which colorectal cancer patients are at risk of their cancer coming back after surgery and if they need extra treatment.

  Recruiting at 9 sites University of Aarhus · Copenhagen, Capital Region of Denmark and 9 other locations · NCT06076811

• Evaluating a new CAR T-cell therapy for solid tumors expressing MSLN

  This study is testing a new CAR T-cell therapy to see if it can safely treat adults with solid tumors like colorectal and lung cancer that express a specific protein.

  Recruiting at 12 sites Phase 1/2 A2 Biotherapeutics Inc. · Gilbert, Arizona and 11 other locations · NCT06051695

• Using a microwave device to improve colonoscopy for detecting polyps

  This study is testing a new microwave device during colonoscopies to see if it can help doctors find more polyps that might be missed with regular methods.

  Recruiting MiWEndo Solutions S.L. · Barcelona · NCT05988645

• Assessing minimal residual disease in colorectal cancer patients

  This study is testing if checking for certain cancer-related markers in the blood can help predict if colorectal cancer will come back after treatment.

  Recruiting M.D. Anderson Cancer Center · Gilbert, Arizona and 9 other locations · NCT04739072

• Testing INBRX-109 for advanced solid tumors including sarcomas

  This study is testing a new treatment called INBRX-109 for people with advanced solid tumors, like Ewing sarcoma and colorectal cancer, to see how safe it is and if it works better with standard chemotherapy.

  Recruiting at 32 sites Phase 1 Inhibrx Biosciences, Inc · Scottsdale, Arizona and 36 other locations · NCT03715933

Related topics

Quick answers

How many Colorectal Adenocarcinoma clinical trials are recruiting right now?

25, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 25 countries. The most sites are in United States (16 trials), Spain (7 trials), France (6 trials), China (5 trials), Italy (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 5, Phase 2: 4, Phase 1/2: 3, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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