Blood test for early detection of colorectal cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to develop a blood test that can detect colorectal cancer at early stages, particularly in individuals with Lynch Syndrome, who are at higher risk for developing this type of cancer. Participants will provide an additional blood sample that will be analyzed for circulating tumor DNA (ctDNA) to identify molecular characteristics indicative of newly arising tumors. The study seeks to optimize the detection of ctDNA without prior tumor information, addressing the limitations of current surveillance methods. By improving early detection, the study hopes to enhance cancer prevention strategies for at-risk populations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

(suspect) Lynch Syndrome carriers who:

* Have proven Lynch Syndrome (MMR-gene or EPCAM mutation), or have a proven microsatellite instability high (MSI-H)tumor;
* Are at least 18 years old; Have been diagnosed with any form of cancer at the time of inclusion, but have had no treatment yet;
* Have granted informed consent to participate in this study.

Exclusion Criteria:

(suspect) Lynch Syndrome carriers who:

* Are unwilling to undergo extra blood sampling;
* Are under the age of 18;
* Have no newly diagnosed tumors at time of inclusion;
* Have been treated for their tumor at time of inclusion;
* Are not able to read or understand Dutch language or are mentally not capable.

Where it's running

• Erasmus MC
  Rotterdam, South Holland, Netherlands Recruiting
• Leiden University Medical Center
  Leiden, South Holland, Netherlands Not yet recruiting

Study contacts

• Principal investigator: Anja Wagner, Dr. — Erasmus Medical Center
• Study coordinator: Lotte van Leeuwen, BSc
• Email: l.vanleeuwen@erasmusmc.nl
• Phone: +31646245198

Similar studies

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.