Effect of Tranexamic Acid on Bleeding in Cardiac Surgery
The Dose Effect of Activated Clotting Time and Tranexamic Acid on Bleeding in Adult Cardiac Surgery
This study is testing how different doses of tranexamic acid can help reduce bleeding and the need for blood transfusions in adults having heart surgery.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Taichung Veterans General Hospital Academic / other |
| Locations | 2 sites (Taichung and 1 other locations) |
| Trial ID | NCT06109155 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the impact of different doses of tranexamic acid and activated clotting time (ACT) levels on bleeding and blood transfusion requirements in adult patients undergoing cardiac surgery. Participants will be divided into four groups based on their tranexamic acid dosage and ACT levels during surgery. The primary outcome measured will be the volume of postoperative bleeding within 24 hours. The study aims to enhance understanding of pharmacological management during cardiac procedures.
Who should consider this trial
Good fit: Ideal candidates are adults scheduled for cardiac surgery requiring cardiopulmonary bypass.
Not a fit: Patients who are pregnant, undergoing emergency procedures, or have severe comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to reduced bleeding and blood transfusion needs in cardiac surgery patients.
How similar studies have performed: Previous studies have shown promising results with tranexamic acid in reducing bleeding in surgical settings, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult, cardiac surgery with cardiopulmonary bypass Exclusion Criteria: * pregnant * emergency procedure * immune compromised * aortic surgery * end-stage renal disease * liver disease * critical status * incomplete clinical data
Where this trial is running
Taichung and 1 other locations
- Taichung Veterans General Hospital — Taichung, Taiwan (Recruiting)
- Taichung Veterans General hospital — Taichung, Taiwan (Recruiting)
Study contacts
- Study coordinator: Yung-Szu Wu, MD
- Email: adconvert98@gmail.com
- Phone: 0423592525
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.