Effects of exosomes on heart injury during heart surgery
Official title: Exosome Mediated Effects on Cardiac Injury during Cardiopulmonary Bypass
Funded at Birmingham VA Medical Center · NIH-11043303 · Data updated 2026-11-12
This study is looking at how tiny particles called exosomes, which come from your cells, might influence heart damage during heart surgery for mitral regurgitation, helping doctors better understand and predict how your heart will recover after the procedure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Birmingham VA Medical Center NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | October 1, 2022 |
| Project end | September 30, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01CX002374-03 |
| Project ID | NIH-11043303 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing surgery for primary mitral regurgitation.
✕Less likely to help
Patients with conditions unrelated to primary mitral regurgitation or those not undergoing cardiopulmonary bypass may not benefit from this research.
What this research studies
This research investigates how exosomes, which are tiny particles released by cells, affect heart injury during cardiopulmonary bypass in patients with primary mitral regurgitation. The study aims to understand the relationship between exosome content and acute cardiac injury, particularly focusing on oxidative stress and inflammation responses. By using advanced imaging techniques like cardiac magnetic resonance, the research seeks to improve predictive models for patient outcomes after heart surgery. Patients may be monitored for changes in heart function and injury markers during and after the surgical procedure.
Why it matters
Potential benefit: If successful, this research could lead to better predictions of heart function recovery after surgery, ultimately improving patient outcomes.
How similar studies have gone: Other research has shown promising results in understanding the role of exosomes in cardiac injury, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Birmingham VA Medical Center
Birmingham, United States Active
Researchers
- Principal investigator: Dell'italia, Louis J. — Birmingham VA Medical Center
- Study coordinator: Dell'italia, Louis J.
Related research
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This study is looking at how red blood cells might cause inflammation during heart surgeries in kids, with the goal of finding ways to reduce this inflammation and help patients recover better after surgery.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.