Optimized Flow for Obese Patients Undergoing Heart Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional trial evaluates whether calculating CPB pump flow based on ideal body weight, rather than actual weight, affects outcomes in obese adults undergoing cardiac surgery. The approach aims to reduce hemodilution and transfusion needs by aligning flow with lean mass, potentially simplifying cannulation and reducing circulation-related stress. Eligible procedures include CABG, valve procedures, and combined surgeries requiring CPB. The study is conducted at CHU Amiens and involves standard CPB and anticoagulation management. Randomization and detailed protocol elements are not provided in the available summary.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged over 18 years
* Patients with obesity (BMI \> 30 kg/m²)
* Scheduled cardiac surgery under cardiopulmonary bypass (CPB):
* Coronary artery bypass grafting (CABG)
* Aortic valve replacement
* Mitral valve repair or replacement
* Surgery on the aortic root (aortic tube, Bentall procedure, Tirone David, or others)
* Combined surgery
* Affiliation to a social security scheme
* Written informed consent

Exclusion Criteria:

* Minors
* BMI \< 30 kg/m²
* Off-pump cardiac surgery
* Surgery on the aortic arch
* Planned perioperative hypothermia \< 32ºC
* Emergency surgery
* Heart transplantation or mechanical circulatory support surgery
* Infectious endocarditis
* Participation in another clinical trial within the past 30 days
* Pregnant, parturient, or breastfeeding women
* Patients under guardianship, curatorship, or deprived of civil rights
* Advanced chronic kidney disease (renal clearance \< 30 ml/min)
* Coexisting disease with a high probability of death within 6 months
* Preoperative anemia (hemoglobin \< 10 g/dL)
* Body surface area (actual body weight) \> 2.5 m²

Where it's running

• CHU Amiens Picardie
  Amiens, France Recruiting

Study contacts

• Study coordinator: Osama ABOU ARAB, Pr
• Email: AbouArab.Osama@chu-amiens.fr
• Phone: 33+3 22 08 78 36

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.