Impact of cardiopulmonary bypass on platelet lipids and bleeding after cardiac surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The PLACARD project investigates how cardiopulmonary bypass alters platelet lipid metabolism and the formation of procoagulant platelets in patients undergoing cardiac surgery. Researchers will analyze platelet lipid profiles and bioenergetics before, during, and after surgery and relate these ex vivo findings to postoperative inflammatory markers and bleeding outcomes in the ICU. The study uses arterial blood sampling at multiple time points to characterize the hemostatic and inflammatory milieu associated with CPB. It aims to clarify whether CPB-induced platelet changes contribute to adverse postoperative events and whether these pathways could be targeted to improve outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (≥ 18 years old) suffering from coronary disease and/or severe valvular dysfunction (mitral or aortic) undergoing elective coronary angiography or cardiac surgery with cardiopulmonary bypass.

Exclusion Criteria:

* Uninterrupted preoperative dual antiplatelet therapy
* Active chronic inflammatory disease
* Recent chemotherapy or immunotherapy (\< 3 months)
* Active solid malignancy
* History of hematologic malignancy
* Hemophilia or other coagulopathy
* History of thrombocytopenia (\< 100,000 platelets/mm³)
* Recent administration of thrombopoietin receptor agonist or immunoglobulins
* History of thrombopathy, thrombocytosis, or myeloproliferative syndrome
* History of heparin-induced thrombocytopenia (HIT)
* Cirrhosis or hepatic fibrosis (with or without hypersplenism)
* History of splenectomy, regardless of initial indication
* History of systemic autoimmune disease (e.g., systemic lupus erythematosus, scleroderma, antiphospholipid syndrome, systemic vasculitis)
* Recent major surgery (\< 3 months)
* Severe renal insufficiency (eGFR ≤ 30 mL/min/m²) with or without dialysis
* Recent or chronic corticosteroid therapy
* Recent acute coronary syndrome, STEMI type (\< 3 months)
* Urgent surgery or procedure
* Preoperative hemodynamic instability

Where it's running

• Cliniques universitaires Saint-Luc
  Brussels, Belgium Recruiting

Study contacts

• Study coordinator: Christophe Beauloye, MD, PhD
• Email: christophe.beauloye@uclouvain.be
• Phone: 003227642812

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.