Global longitudinal strain to predict difficult separation from cardiopulmonary bypass

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, multicenter observational study will measure GLS by speckle-tracking echocardiography before and after elective cardiac surgery that uses cardiopulmonary bypass. Patients undergoing procedures such as isolated valve surgery, CABG, combined valve+CABG, or ascending aorta operations will have perioperative echocardiograms and routine postoperative monitoring. The study will compare preoperative GLS and perioperative changes with intraoperative difficulty separating from bypass and with outcomes including ICU stay, hospital length of stay, cardiac biomarkers, and 30-day mortality. Exclusions include emergency or redo surgery, active preoperative mechanical support, ongoing inotropes, mechanical ventilation, and preoperative atrial fibrillation.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Age \> 18 years.
* Scheduled for elective cardiac surgery requiring cardiopulmonary bypass (CPB).
* Provided written informed consent to participate.
* Eligible surgical procedures include:

  * Isolated mitral valve replacement or repair.
  * Isolated aortic valve replacement or repair.
  * Isolated coronary artery bypass grafting (CABG).
  * Combined valve and CABG surgery.
  * Multiple valve replacement or repair.
  * Surgery involving the ascending aorta or aortic arch.

Exclusion Criteria

* Emergency cardiac surgery.
* Redo cardiac surgery.
* Contraindications to transesophageal echocardiography (TEE).
* Critical preoperative conditions, including:

  * Ongoing inotropic drug therapy.
  * Preoperative mechanical circulatory support (e.g., IABP, ECMO, VAD).
  * Requirement for mechanical ventilation.
  * Preoperative atrial fibrillation.

Where it's running

• University of Rome Tor Vergata
  Rome, Italy Recruiting
• Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
  Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Mustafa E Gurcu, MD
• Email: emregurcu@gmail.com
• Phone: +905058917800

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.