Milrinone vs Epinephrine on TAPSE after cardiopulmonary bypass
Official title: Milrinone Versus Epinephrine for Right Ventricular Dysfunction After Cardiac Surgery in Adults: A Randomized Double-Blinded Trial
Run by Mansoura University · NCT07144267 · Data updated 2026-11-12
This study tests whether milrinone or epinephrine better supports right ventricular function (TAPSE) after cardiac surgery with CPB in adults.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 102 (estimated) |
| Sponsor | Mansoura University Academic / other |
| Locations | 1 site (Al Mansurah) |
| Status | Recruiting |
| Started | March 1, 2026 |
| Main results expected | December 30, 2028 |
| Study ends | March 30, 2029 |
| Registry record updated | October 13, 2026 |
| Trial ID | NCT07144267 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–70 undergoing CPB with TAPSE < 1.7 cm and preserved ejection fraction (>40%), ASA II–III, without major contraindications to TEE or significant renal/hepatic disease.
✕Probably not a fit
Patients with preoperative RV impairment, severe pulmonary hypertension, redo surgeries, or significant organ dysfunction may not benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study compares two inotropes, milrinone and epinephrine, to see which more effectively supports right ventricular function after cardiopulmonary bypass. Eligible adults undergoing CPB with adequate ejection fraction and TAPSE below a threshold will be randomized to receive one of the two drugs. The trial evaluates changes in TAPSE and related hemodynamics to determine which agent better preserves right ventricular performance in the immediate postoperative period. Safety and tolerability of both agents will be monitored per standard perioperative care. The investigation is conducted at Mansoura University Hospitals with sponsor support from Mansoura University.
Why it matters
Potential benefit: If successful, the findings could help tailor inotrope choice to protect right heart function after CPB, potentially reducing complications and improving recovery.
How similar studies have gone: Prior research supports distinct hemodynamic effects of milrinone and epinephrine in cardiac surgery, but direct head-to-head data on TAPSE after CPB are limited, making this approach relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status II \& III * Age between 18 and 70 years * Both Gender * Body mass index less than 40 kg/m2 * Ejection fraction of \>40% * Tricuspid annular plane systolic excursion (TAPSE) \< 1.7cm Exclusion Criteria: * Patient refusal. * Preoperative RV impairment * Pulmonary hypertension (estimated pulmonary artery systolic pressure \> 50 mmHg) * Patients with any contraindications to Transesophageal echocardiography (TEE) * Redo or Re-exploration surgery * Patients with chronic kidney disease (serum creatinine \> 1.5 mg/ dl) * Patients with chronic liver disease (child pugh B and C)
Where it's running
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Mansoura University Hospitals
Al Mansurah, Egypt Recruiting
Study contacts
- Study coordinator: Maha A AboZeid, Assistant professor
- Email: mahazed@yahoo.com
- Phone: 01019216192
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.