How red blood cells affect inflammation during heart surgery in children
Mechanisms by which red blood cells contribute cardiopulmonary bypass associated inflammation
This study is looking at how red blood cells might cause inflammation during heart surgeries in kids, with the goal of finding ways to reduce this inflammation and help patients recover better after surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11075884 on NIH RePORTER |
What this research studies
This research investigates the role of red blood cells in causing inflammation during cardiopulmonary bypass (CPB) in pediatric heart surgeries. It aims to understand how these cells contribute to systemic inflammation and multi-organ dysfunction that can occur after surgery. By examining the effects of both endogenous and exogenous red blood cells during CPB, the study seeks to develop new strategies to reduce inflammation and improve patient outcomes. The research will utilize animal models to explore the physiological changes in red blood cells under the stress of CPB.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are scheduled for congenital heart defect surgeries involving cardiopulmonary bypass.
Not a fit: Patients who are not undergoing cardiac surgery or those older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved surgical techniques and treatments that minimize inflammation and enhance recovery for children undergoing heart surgery.
How similar studies have performed: Previous research has shown that understanding the role of red blood cells in inflammation can lead to significant advancements in surgical outcomes, suggesting that this approach has potential for success.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Nigam, Vishal — Seattle Children's Hospital
- Study coordinator: Nigam, Vishal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.