How red blood cells affect inflammation during heart surgery in children
Official title: Mechanisms by which red blood cells contribute cardiopulmonary bypass associated inflammation
Funded at Seattle Children's Hospital · NIH-11075884 · Data updated 2026-11-12
This study is looking at how red blood cells might cause inflammation during heart surgeries in kids, with the goal of finding ways to reduce this inflammation and help patients recover better after surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $753,324 |
| NIH project number | 5R01HL170607-02 |
| Project ID | NIH-11075884 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are scheduled for congenital heart defect surgeries involving cardiopulmonary bypass.
✕Less likely to help
Patients who are not undergoing cardiac surgery or those older than 11 years may not benefit from this research.
What this research studies
This research investigates the role of red blood cells in causing inflammation during cardiopulmonary bypass (CPB) in pediatric heart surgeries. It aims to understand how these cells contribute to systemic inflammation and multi-organ dysfunction that can occur after surgery. By examining the effects of both endogenous and exogenous red blood cells during CPB, the study seeks to develop new strategies to reduce inflammation and improve patient outcomes. The research will utilize animal models to explore the physiological changes in red blood cells under the stress of CPB.
Why it matters
Potential benefit: If successful, this research could lead to improved surgical techniques and treatments that minimize inflammation and enhance recovery for children undergoing heart surgery.
How similar studies have gone: Previous research has shown that understanding the role of red blood cells in inflammation can lead to significant advancements in surgical outcomes, suggesting that this approach has potential for success.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Nigam, Vishal — Seattle Children's Hospital
- Study coordinator: Nigam, Vishal
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This study is looking at how a heart-lung machine used during heart surgery for kids can cause inflammation in their bodies, and it aims to find ways to reduce this inflammation to help them recover better after surgery.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.