Understanding how heart-lung machines affect inflammation in children during surgery
Supraphysiologic Shear Stresses Associated with Cardiopulmonary Bypass are Sufficient to Activate RIKP3 Signaling
['FUNDING_R01'] · SEATTLE CHILDREN'S HOSPITAL · NIH-11035150
This study is looking at how a heart-lung machine used during heart surgery for kids can cause inflammation in their bodies, and it aims to find ways to reduce this inflammation to help them recover better after surgery.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SEATTLE CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11035150 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of cardiopulmonary bypass (CPB) on inflammation in pediatric patients undergoing open-heart surgery. It focuses on how high shear stress from the CPB circuit activates specific signaling pathways in blood cells, leading to systemic inflammation and multi-organ dysfunction. By studying both animal models and patient data, the research aims to identify potential treatments that could mitigate these inflammatory responses and improve surgical outcomes for children. The ultimate goal is to translate these findings into clinical strategies that enhance recovery for neonatal cardiac surgery patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are pediatric patients, particularly neonates, who are scheduled to undergo open-heart surgery requiring cardiopulmonary bypass.
Not a fit: Patients who are not undergoing cardiac surgery or who do not require cardiopulmonary bypass may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that reduce inflammation and enhance recovery for children undergoing heart surgery.
How similar studies have performed: Previous research has indicated that targeting specific signaling pathways can effectively reduce inflammation in similar contexts, suggesting a promising avenue for this study.
Where this research is happening
SEATTLE, UNITED STATES
- SEATTLE CHILDREN'S HOSPITAL — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NIGAM, VISHAL — SEATTLE CHILDREN'S HOSPITAL
- Study coordinator: NIGAM, VISHAL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.