Understanding how heart-lung machines affect inflammation in children during surgery
Official title: Supraphysiologic Shear Stresses Associated with Cardiopulmonary Bypass are Sufficient to Activate RIKP3 Signaling
Funded at Seattle Children's Hospital · NIH-11035150 · Data updated 2026-11-12
This study is looking at how a heart-lung machine used during heart surgery for kids can cause inflammation in their bodies, and it aims to find ways to reduce this inflammation to help them recover better after surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | April 11, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $770,727 |
| NIH project number | 5R01HD106628-04 |
| Project ID | NIH-11035150 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pediatric patients, particularly neonates, who are scheduled to undergo open-heart surgery requiring cardiopulmonary bypass.
✕Less likely to help
Patients who are not undergoing cardiac surgery or who do not require cardiopulmonary bypass may not benefit from this research.
What this research studies
This research investigates the effects of cardiopulmonary bypass (CPB) on inflammation in pediatric patients undergoing open-heart surgery. It focuses on how high shear stress from the CPB circuit activates specific signaling pathways in blood cells, leading to systemic inflammation and multi-organ dysfunction. By studying both animal models and patient data, the research aims to identify potential treatments that could mitigate these inflammatory responses and improve surgical outcomes for children. The ultimate goal is to translate these findings into clinical strategies that enhance recovery for neonatal cardiac surgery patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that reduce inflammation and enhance recovery for children undergoing heart surgery.
How similar studies have gone: Previous research has indicated that targeting specific signaling pathways can effectively reduce inflammation in similar contexts, suggesting a promising avenue for this study.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Nigam, Vishal — Seattle Children's Hospital
- Study coordinator: Nigam, Vishal
Related research
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-
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This study is looking at how red blood cells might cause inflammation during heart surgeries in kids, with the goal of finding ways to reduce this inflammation and help patients recover better after surgery.
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This study is looking at how tiny particles called exosomes, which come from your cells, might influence heart damage during heart surgery for mitral regurgitation, helping doctors better understand and predict how your heart will recover after the procedure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.