Comparing heart surgery methods to protect brain health
Official title: Neurometabolic Outcomes of Different Cardiopulmonary Bypass Strategies
Funded at Stanford University · NIH-10773170 · Data updated 2026-11-12
This study is looking at how two different heart surgery methods might affect brain health in kids with congenital heart diseases, to see which one helps protect their brain better during surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | February 15, 2021 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $676,868 |
| NIH project number | 5R01HL152757-04 |
| Project ID | NIH-10773170 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are children with congenital cardiac diseases who require surgery involving cardiopulmonary bypass.
✕Less likely to help
Patients who do not have congenital heart conditions or those not undergoing surgery requiring cardiopulmonary bypass may not benefit from this research.
What this research studies
This research investigates the effects of two different cardiopulmonary bypass (CPB) strategies on brain health in patients with congenital heart diseases. It focuses on how these methods, Deep Hypothermic Circulatory Arrest (DHCA) and Antegrade Cerebral Perfusion (ACP), impact neurodevelopment and brain metabolism during surgery. By using advanced MRI and magnetic resonance spectroscopy techniques, the study aims to measure real-time changes in brain metabolites and energy levels, providing insights into which method may better protect brain function. The findings could lead to improved surgical practices and outcomes for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to better surgical techniques that minimize neurodevelopmental risks for children undergoing heart surgery.
How similar studies have gone: While there is ongoing debate about the effectiveness of these CPB strategies, this research aims to provide objective data that could clarify their impacts, making it a novel approach.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Hanley, Frank — Stanford University
- Study coordinator: Hanley, Frank
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.