Using Nitric Oxide to Improve Recovery in Heart Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the use of inhaled nitric oxide therapy in adult patients undergoing elective cardiac surgery that requires cardiopulmonary bypass. The study aims to assess whether nitric oxide can reduce postoperative complications such as acute kidney injury and respiratory failure, which are common in cardiac surgery. Participants will be randomly assigned to receive either nitric oxide or standard care during their surgery. The trial seeks to determine the efficacy of this treatment in improving patient outcomes and reducing the need for intensive support post-surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 years.
2. Elective cardiac or aortic surgery requiring CPB
3. Without history of previous open heart surgery.

Exclusion Criteria:

1. Immediate emergency cardiac surgery;
2. Cardiac surgery that requires deep hypothermic circulatory arrest;
3. Planned cardiac surgery for congenital heart disease repair;
4. Planned for heart transplatation
5. Ongoing heart failure or low output syndrome already on intensive support (IABP, ECMO, left ventricular assist device such as impella, mechanical ventilation), left ventricular ejection fraction of \< 30% or comparable, equivalent preoperative conditions
6. Already accepted or currently on inhaled NO therapy or inhaled/aerosolized prostacyclin in the week prior to the enrollment;
7. Endstage kidney disease with estimated glomerular filtration rate (eGFR) \< 15 ml/min or already on renal replacement surgery.
8. Hemophilia A or B
9. Other terminal stage of chronic disease with life expectancy less than 1 year per evaluation and adjudication of the attending physicians.

Where it's running

• Xijing Hospital
  Xi'an, Shaanxi, China Recruiting
• Massachusetts General Hospital, Department of Anesthesia, Critical Care and Pain Medicine
  Boston, Massachusetts, United States Not yet recruiting
• Cardiology Research Institute, Tomsk National Research Medical Center
  Tomsk, Russia Not yet recruiting

Study contacts

• Principal investigator: Chong Lei, M.D., & phd — Xijing Hospital
• Study coordinator: Chong Lei, M.D., & phd
• Email: crystalleichong@126.com
• Phone: 18629011362

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Integrated intraoperative hemodynamic monitoring during cardiac surgery with CPB

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• Impact of cardiopulmonary bypass on platelet lipids and bleeding after cardiac surgery

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• Transcutaneous auricular vagus nerve stimulation to prevent kidney injury after heart surgery

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• Eurosets arterial and venous cannulas for cardiopulmonary bypass procedures

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• Personalized lung volume optimization with PEEP titration for children after heart surgery or with severe respiratory failure

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  Recruiting Phase 1/2 Charite University, Berlin, Germany · Tübingen · NCT07193719

• Autologous Cold-Stored Platelets for Complex Cardiac Surgery

  This study tests whether using a patient’s own cold-stored platelets, donated 7–10 days before surgery, improves outcomes for adults undergoing complex cardiac procedures compared with standard allogeneic platelets.

  Recruiting Phase 2/3 University Health Network, Toronto · Toronto, Ontario · NCT07064954

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.