Understanding how cell-free hemoglobin affects kidney injury after heart surgery in children
Mechanisms of Cell-Free Plasma Hemoglobin-Mediated Renal Injury after Cardiopulmonary Bypass
This study is looking at how a substance called cell-free plasma hemoglobin, which can be released during heart surgeries in kids, might lead to kidney problems, and it aims to find ways to help protect their kidneys during these procedures.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10654592 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cell-free plasma hemoglobin, produced during cardiopulmonary bypass in pediatric heart surgeries, contributes to acute kidney injury. The study aims to identify the pathophysiological processes involved and explore potential therapeutic targets through both clinical observations and an in vivo rodent model. By examining the relationship between hemoglobin levels, oxidative stress, and kidney function, the research seeks to improve outcomes for children undergoing these procedures.
Who could benefit from this research
Good fit: Ideal candidates for this research are children undergoing cardiopulmonary bypass during cardiac surgery.
Not a fit: Patients who are not undergoing cardiopulmonary bypass or those with pre-existing severe kidney conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing kidney injury in children after heart surgery.
How similar studies have performed: Previous research has indicated a link between cell-free hemoglobin and kidney injury, suggesting that this approach may yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Kim-Campbell, Nahmah — University of Pittsburgh at Pittsburgh
- Study coordinator: Kim-Campbell, Nahmah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.