Understanding heart rhythm problems linked to specific proteins in heart cells
Official title: Arrhythmia Mechanisms Modulated by Intercalated Disc Extracellular Nanodomains
Funded at Virginia Polytechnic Inst and St Univ · NIH-11045714 · Data updated 2026-11-12
This study is looking at how specific genetic changes can cause heart rhythm problems like Brugada Syndrome and Arrhythmogenic Cardiomyopathy, and it aims to find new ways to help people with these conditions feel better and stay safe.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project start | April 1, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $567,359 |
| NIH project number | 5R01HL159097-03 |
| Project ID | NIH-11045714 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Brugada Syndrome or Arrhythmogenic Cardiomyopathy.
✕Less likely to help
Patients with other types of heart rhythm disorders unrelated to the specific genetic mutations being studied may not benefit from this research.
What this research studies
This research investigates how certain genetic mutations affect heart rhythm disorders, specifically Brugada Syndrome and Arrhythmogenic Cardiomyopathy. By studying the role of intercalated disc proteins and how they interact under different conditions, the researchers aim to uncover mechanisms that lead to these arrhythmias. The approach includes using animal models to simulate human heart conditions and examining how changes in the heart's environment can reveal hidden issues. The ultimate goal is to identify potential treatments that could improve heart function and prevent dangerous arrhythmias.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for patients suffering from serious heart rhythm disorders.
How similar studies have gone: Previous research has shown promising results in understanding heart rhythm disorders through similar approaches, suggesting potential for success in this study.
Where this research is happening
-
Virginia Polytechnic Inst and St Univ
Blacksburg, United States Active
Researchers
- Principal investigator: Poelzing, Steven — Virginia Polytechnic Inst and St Univ
- Study coordinator: Poelzing, Steven
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.