Investigating how large ion channels contribute to heart rhythm problems
Non-selective Large Conductance Ion Channels In Triggered Arrhythmia
This study is looking at how too much calcium in heart cells can cause dangerous heart rhythms, and it's for anyone interested in understanding how we might prevent sudden heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11056861 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind triggered arrhythmias, particularly how excessive calcium in heart cells can lead to dangerous heart rhythms. By studying the role of large conductance ion channels and their activation, the research aims to uncover how these channels contribute to abnormal electrical activity in the heart. The approach involves examining cellular behaviors and interactions in cardiac tissues, which could provide insights into preventing sudden cardiac death.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 who have experienced or are at risk for triggered arrhythmias, particularly those with a history of cardiac conditions.
Not a fit: Patients with arrhythmias not related to calcium handling or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent life-threatening heart rhythm disorders.
How similar studies have performed: Previous research has shown promising results in understanding arrhythmias through similar cellular mechanisms, indicating potential for success in this area.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Kryshtal, Dmytro O. — Vanderbilt University Medical Center
- Study coordinator: Kryshtal, Dmytro O.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.