Investigating how large ion channels contribute to heart rhythm problems
Official title: Non-selective Large Conductance Ion Channels In Triggered Arrhythmia
Funded at Vanderbilt University Medical Center · NIH-11056861 · Data updated 2026-11-12
This study is looking at how too much calcium in heart cells can cause dangerous heart rhythms, and it's for anyone interested in understanding how we might prevent sudden heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $491,719 |
| NIH project number | 5R01HL164820-02 |
| Project ID | NIH-11056861 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 who have experienced or are at risk for triggered arrhythmias, particularly those with a history of cardiac conditions.
✕Less likely to help
Patients with arrhythmias not related to calcium handling or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on understanding the mechanisms behind triggered arrhythmias, particularly how excessive calcium in heart cells can lead to dangerous heart rhythms. By studying the role of large conductance ion channels and their activation, the research aims to uncover how these channels contribute to abnormal electrical activity in the heart. The approach involves examining cellular behaviors and interactions in cardiac tissues, which could provide insights into preventing sudden cardiac death.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent life-threatening heart rhythm disorders.
How similar studies have gone: Previous research has shown promising results in understanding arrhythmias through similar cellular mechanisms, indicating potential for success in this area.
Where this research is happening
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Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Kryshtal, Dmytro O. — Vanderbilt University Medical Center
- Study coordinator: Kryshtal, Dmytro O.
Related research
Other NIH-funded projects on the same topics.
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This NIH grant studies how changes in the heart’s nerve signaling after a heart attack lead to dangerous rhythm problems, with the goal of finding ways to prevent them.
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Understanding fat deposits after heart attack and their link to dangerous heart rhythms
A Penn Medicine team is studying how fat buildup in the heart after a heart attack may influence dangerous heart rhythms and recovery.
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Developing 3D Real-Time CMR for Arrhythmia Imaging
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.