NIH-funded research R01 grant

Precision imaging of heart rhythms to map arrhythmias without surgery

Official title: Precision imaging of electromechanical coupling for non-invasive cardiac arrhythmia mapping

Funded at Columbia University Health Sciences · NIH-11385556 · Data updated 2026-11-12

A new 3D ultrasound method could noninvasively map how abnormal heart rhythms start and travel, helping doctors plan safer treatments for people with arrhythmias.

More Arrhythmia research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionColumbia University Health Sciences
NIH-funded
Lab location1 site (New York, United States)
Project startSeptember 17, 2024
Project endJune 30, 2029
Funding year2026
Award (this year)$707,787
NIH project number5R01HL170606-03
Project IDNIH-11385556 on NIH RePORTER

Who could benefit from this research

Could help

Adults with suspected or known cardiac arrhythmias who are candidates for noninvasive diagnostic mapping and potential ablation.

Less likely to help

Individuals without arrhythmias or those not undergoing diagnostic mapping or ablation may not benefit.

What this research studies

This project aims to advance Electromechanical Wave Imaging (EWI) into a full 3D, noninvasive mapping approach for cardiac arrhythmias. It seeks to visualize electromechanical coupling in the heart to pinpoint arrhythmia origins without radiation or costly scans. By collaborating across cardiology and biomedical engineering at Columbia, the team will test the 3D EWI technique in adults undergoing evaluation for arrhythmias to improve diagnosis and planning for ablation.

Why it matters

Potential benefit: If successful, patients could receive more accurate, noninvasive guidance for catheter ablation, reducing procedure time and radiation exposure.

How similar studies have gone: Previous noninvasive mapping efforts like ECG imaging have shown promise, but 3D ultrasound-based EWI is a novel approach with ongoing validation.

Where this research is happening

  • Columbia University Health Sciences
    New York, United States
    Active

Researchers

  • Principal investigator: Wan, Elaine Y — Columbia University Health Sciences
  • Study coordinator: Wan, Elaine Y

Related research

Other NIH-funded projects on the same topics.

  • New roles for a heart protein in preventing dangerous rhythms

    A heart study will explore how a specific protein regulator (PP2A) affects ion channels that control heartbeat, with the goal of reducing dangerous arrhythmias.

    NIH research Ohio State University · Columbus, UNITED STATES · NIH-11375997

  • Understanding how small potassium channels affect heart rhythm and disease

    Aims to understand how tiny calcium-activated potassium channels influence heart rhythm and potentially lead to new treatments for atrial fibrillation and heart failure.

    NIH research University of Arizona · Tucson, United States · NIH-11294983

  • 3D ultrasound mapping to locate sources of abnormal heart rhythms

    This project uses a fast, radiation-free 3D ultrasound method to find where irregular heartbeats start in adults with arrhythmias.

    NIH research Columbia University Health Sciences · New York, United States · NIH-11193775

  • Understanding a New Way to Control Heart Rhythm Problems

    This work explores how a specific protein in the heart helps regulate electrical signals, aiming to find new ways to prevent dangerous heart rhythm issues.

    NIH research Ohio State University · Columbus, UNITED STATES · NIH-11128719

  • Exploring the mechanisms behind heart rhythm disorders

    This conference is all about helping doctors and researchers understand what causes irregular heartbeats, so they can find better ways to diagnose and treat these issues for people at risk of serious health problems like strokes or sudden heart failure.

    NIH research Gordon Research Conferences · East Greenwich, UNITED STATES · NIH-11065758

  • AI and 4D ultrasound to pinpoint where abnormal heart rhythms begin

    Uses AI together with time-resolved 3D (4D) ultrasound to find where abnormal heart rhythms start in people with arrhythmias.

    NIH research University of California, San Francisco · San Francisco, United States · NIH-11062814

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.