Understanding how lysosomes affect heart rhythm
Official title: Lysosomes and arrhythmia
Funded at University of Minnesota · NIH-11071049 · Data updated 2026-11-12
This study is looking at how tiny parts of your cells called lysosomes might affect heart rhythms in people with cardiomyopathy, helping us understand why some people experience irregular heartbeats and how we can improve heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | January 10, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $673,642 |
| NIH project number | 1R01HL177974-01 |
| Project ID | NIH-11071049 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with cardiomyopathy or those at high risk for sudden cardiac death.
✕Less likely to help
Patients without any history of heart disease or arrhythmias may not benefit from this research.
What this research studies
This research investigates the role of lysosomes in causing irregular heart rhythms, particularly in patients with cardiomyopathy. It explores how these organelles, which are typically involved in breaking down waste in cells, can also influence calcium levels that are critical for heart function. By examining the interactions between lysosomes and other cellular structures, the study aims to identify new mechanisms that contribute to arrhythmias and sudden cardiac death. The approach includes detailed cellular experiments to understand how lysosomal activity can impact heart rhythm stability.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent life-threatening heart arrhythmias.
How similar studies have gone: Previous research has shown that targeting cellular mechanisms related to calcium handling can improve outcomes in patients with arrhythmias, suggesting potential success for this novel approach.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Dudley, Samuel C — University of Minnesota
- Study coordinator: Dudley, Samuel C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.